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题名:
A Highly Efficient Synthetic Vector: Nonhydrodynamic Delivery of DNA to Hepatocyte Nuclei in Vivo
作者: Hu YunXia(胡云霞) ; Haynes, Matthew T. ; Wang, Yuhua ; Liu, Feng ; Huang, Leaf
刊名: ACS NANO
ISSN号: 1936-0851
出版日期: 2013-06
卷号: 7, 期号:6, 页码:5376-5384
关键词: nanoparticle ; liposome ; liver ; hepatocyte ; DNA delivery ; arginine-rich peptide
学科分类: Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
产权排序: [Hu, Yunxia; Haynes, Matthew T.; Wang, Yuhua; Liu, Feng; Huang, Leaf] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA
通讯作者: Hu, YX (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, 17 Chun Hui Rd, Yantai 264003, Shandong, Peoples R China. yunxiahu@yic.ac.cn ; leafh@unc.edu
中文摘要: Multifunctional membrane-core nanoparticles, composed of calcium phosphate cores, arginine-rich peptides, cationic and PEGylated lipid membranes, and galactose targeting ligands, have been developed as synthetic vectors for efficient nuclear delivery of plasmid DNA and subsequent gene expression in hepatocytes in vivo. Targeted particles exhibited rapid and extensive hepatic accumulation and were predominantly internalized by hepatocytes, while the Inclusion of such peptides in Le was sufficient to elicit high degrees of nuclear translocation of plasmid DNA. Monocyclic CR8C significantly enhanced In vivo gene expression over 10-fold more than linear CR8C, likely due to a release-favoring mechanism of the DNA/peptide complex. Though 100-fold lower in activity than that achieved via hydrodynamic injection, this formulation presents as a much less invasive alternative. To our knowledge, this is the most effective synthetic vector for liver gene transfer.
收录类别: SCI
原文出处: 查看原文
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/7058
Appears in Collections:山东省海岸带环境工程技术研究中心_期刊论文

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Recommended Citation:
Hu, Yunxia,Haynes, Matthew T.,Wang, Yuhua,et al. A Highly Efficient Synthetic Vector: Nonhydrodynamic Delivery of DNA to Hepatocyte Nuclei in Vivo[J]. ACS NANO,2013,7(6):5376-5384.
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