| Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum | |
Zhou, Jun1,3; Yang, Cuiyun1 ; Wang, Jianhua1; Sun, Pengcheng1,2; Fan, Ping2; Tian, Kai1; Liu, Sujing1; Xia, Chuanhai1
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| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
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| ISSN | 0730-7268 |
| 2013-04-01 | |
| 卷号 | 32期号:4页码:802-809 |
| 关键词 | Antifoulant Nonivamide Phaeodactylum Tricornutum Reactive Oxygen Species |
| 产权排序 | [Zhou, Jun; Yang, Cuiyun; Wang, Jianhua; Sun, Pengcheng; Tian, Kai; Liu, Sujing; Xia, Chuanhai] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing 100864, Shandong, Peoples R China; [Sun, Pengcheng; Fan, Ping] Liaoning Univ, Sch Chem, Shenyang 110036, Liaoning, Peoples R China; [Zhou, Jun] Univ Chinese Acad Sci, Beijing, Peoples R China |
| 通讯作者 | Xia, CH (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing 100864, Shandong, Peoples R China. chxia@yic.ac.cn |
| 作者部门 | 海岸带生物学与生物资源利用所重点实验室 |
| 英文摘要 | Nonivamide, a synthetic derivate of natural capsaicin, has an effective antifouling activity. However, the poor understanding of the toxicity mechanism limits the application of nonivamide in antifouling paints. The present study investigated the inhibitory effects and toxicity mechanism of nonivamide on Phaeodactylum tricornutum. Under a 1.5x105 cells/ml of initial algal density (IAD), the effective concentration causing 50% inhibition at 4- d (4 d-EC50) value of nonivamide was 5.1mg/L. Reactive oxygen species (ROS) level was significantly increased in nonivamide-treated algae. Algal antioxidants, including catalases (CAT), peroxidases (POD), superoxide dismutases (SOD), and glutathione (GSH), were all stimulated by the ROS burst. The excessive ROS substances led to the loss of algal photosynthetic pigments and also damage to the integrity of the lipid membrane. Furthermore, ROS-related genes, including psbA, psbD, psaB, rbcL, nad1, and cob, were found to be suppressed in the chloroplasts and mitochondria of nonivamide-treated algae, and the concentration of cytoplasmic Ca2+, an important regulator of chloroplast and mitochondrion, was elevated. The present study demonstrates that nonivamide could cause peroxidative damages to P. tricornutum by inducing ROS overproduction, which may be initiated by the suppression of ROS-related genes in algal chloroplasts and mitochondria. Environ. Toxicol. Chem. 2013;32:802809. (c) 2013 SETAC; Nonivamide, a synthetic derivate of natural capsaicin, has an effective antifouling activity. However, the poor understanding of the toxicity mechanism limits the application of nonivamide in antifouling paints. The present study investigated the inhibitory effects and toxicity mechanism of nonivamide on Phaeodactylum tricornutum. Under a 1.5x105 cells/ml of initial algal density (IAD), the effective concentration causing 50% inhibition at 4- d (4 d-EC50) value of nonivamide was 5.1mg/L. Reactive oxygen species (ROS) level was significantly increased in nonivamide-treated algae. Algal antioxidants, including catalases (CAT), peroxidases (POD), superoxide dismutases (SOD), and glutathione (GSH), were all stimulated by the ROS burst. The excessive ROS substances led to the loss of algal photosynthetic pigments and also damage to the integrity of the lipid membrane. Furthermore, ROS-related genes, including psbA, psbD, psaB, rbcL, nad1, and cob, were found to be suppressed in the chloroplasts and mitochondria of nonivamide-treated algae, and the concentration of cytoplasmic Ca2+, an important regulator of chloroplast and mitochondrion, was elevated. The present study demonstrates that nonivamide could cause peroxidative damages to P. tricornutum by inducing ROS overproduction, which may be initiated by the suppression of ROS-related genes in algal chloroplasts and mitochondria. Environ. Toxicol. Chem. 2013;32:802809. (c) 2013 SETAC |
| 文章类型 | Article |
| 资助机构 | National Science and Technology Supporting Item [2011BAC02B04]; National High Technology Research and Development Program of China [2010AA065105]; Chinese Academy of Sciences and Local Governments [Y12B051011]; Yantai Science and Technology Bureau [2011063] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | GENE-EXPRESSION ; BALANUS-IMPROVISUS ; OXIDATIVE STRESS ; CAPSAICIN ; PLANTS ; TECHNOLOGY ; SETTLEMENT ; BIOCIDES ; CHANNELS ; CELLS |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Toxicology |
| WOS记录号 | WOS:000316621700011 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/6470 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing 100864, Shandong, Peoples R China 2.Liaoning Univ, Sch Chem, Shenyang 110036, Liaoning, Peoples R China 3.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Jun,Yang, Cuiyun,Wang, Jianhua,et al. Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum[J]. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,2013,32(4):802-809. |
| APA | Zhou, Jun.,Yang, Cuiyun.,Wang, Jianhua.,Sun, Pengcheng.,Fan, Ping.,...&Xia, Chuanhai.(2013).Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum.ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY,32(4),802-809. |
| MLA | Zhou, Jun,et al."Toxic effects of environment-friendly antifoulant nonivamide on Phaeodactylum tricornutum".ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY 32.4(2013):802-809. |
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