| Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway | |
Zhou, Hailong1,2,3,4; Wu, Huifeng1 ; Liao, Chunyang1; Diao, Xiaoping2; Zhen, Jiping2; Chen, Linlin1; Xue, Qinzhao1
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| 发表期刊 | TOXICOLOGY MECHANISMS AND METHODS
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| ISSN | 1537-6524 |
| 2010-07-01 | |
| 卷号 | 20期号:6页码:279-286 |
| 关键词 | Persistent Organic Pollutants Ahr Pathway Toxicology Mechanism Fish |
| 产权排序 | [Zhou, Hailong; Wu, Huifeng; Liao, Chunyang; Chen, Linlin; Xue, Qinzhao] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhou, Hailong; Diao, Xiaoping; Zhen, Jiping] Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China; [Zhou, Hailong] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 通讯作者 | Xue, QZ, Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 作者部门 | 污染过程与控制实验室 |
| 英文摘要 | With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish.; With the development of industry and agriculture, the cases of cancer and tumor have been increasing gradually in the last 30 years, and quite a few cases are caused by persistent organic pollutants (POPs), some of them belonging to environmental endocrine disruptors, and they have become ubiquitous in the environment, especially in the aquatic ecosystem; so this issue has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in fish. In order to gain a comprehensive understanding of the AhR pathway, the present paper focuses on reviewing it from four major steps, including formation of cytosolic complex, translocation of AhR, heterodimerization of AhR, and induction of CYP1A. This study summarized the isoform numbers of AhR pathway genes and the expression patterns in the regulation process of POPs toxicology in zebrafish. |
| 文章类型 | Review |
| 资助机构 | Chinese Academy of Sciences [KZCX2-YW-Q07-05, KZCX2-YW-Q07-04]; Yantai municipal Science and technology development program [2007323]; Science and technology bureau of Yantai city [2009164]; Natural Science Foundation of Hainan Province [309010]; Education Department of Hainan Province [Hj2009-21] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ARYL-HYDROCARBON RECEPTOR ; HEAT-SHOCK-PROTEIN ; NUCLEAR-LOCALIZATION SIGNAL ; POLYCYCLIC AROMATIC-HYDROCARBONS ; X-ASSOCIATED PROTEIN-2 ; ZEBRAFISH DANIO-RERIO ; CO-CHAPERONE P23 ; DIOXIN RECEPTOR ; DNA-BINDING ; NUCLEOCYTOPLASMIC TRANSPORT |
| 研究领域[WOS] | Toxicology |
| WOS记录号 | WOS:000280402000001 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/3801 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 中国科学院烟台海岸带研究所知识产出 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Hainan Univ, Dept Biotechnol, Coll Agr, Haikou 570228, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Hailong,Wu, Huifeng,Liao, Chunyang,et al. Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway[J]. TOXICOLOGY MECHANISMS AND METHODS,2010,20(6):279-286. |
| APA | Zhou, Hailong.,Wu, Huifeng.,Liao, Chunyang.,Diao, Xiaoping.,Zhen, Jiping.,...&Xue, Qinzhao.(2010).Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway.TOXICOLOGY MECHANISMS AND METHODS,20(6),279-286. |
| MLA | Zhou, Hailong,et al."Toxicology mechanism of the persistent organic pollutants (POPs) in fish through AhR pathway".TOXICOLOGY MECHANISMS AND METHODS 20.6(2010):279-286. |
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