| Molecular fluorescent probes for monitoring pH changes in living cells | |
Wang, Rui1; Yu, Chunwei1,2; Yu, Fabiao1; Chen, Lingxin1
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| 2010-10-01 | |
| 发表期刊 | TRAC-TRENDS IN ANALYTICAL CHEMISTRY
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| ISSN | 0165-9936 |
| 卷号 | 29期号:9页码:1004-1013 |
| 产权排序 | [Wang, Rui; Yu, Chunwei; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yu, Chunwei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 摘要 | The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.; The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved. |
| 通讯作者 | Chen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China |
| 关键词 | Fluorescence Microscopy Fluorescent Probe Intracellular Ph Living Cell Organic Synthesis Ph Detection Ph Indicator Ph Regulation Signal Transduction Small Molecular Probe |
| 作者部门 | 环境化学实验室 |
| 学科领域 | Chemistry, Analytical |
| 项目资助者 | Department of Science and Technology of Shandong Province of China [2008GG20005005]; National Natural Science Foundation of China [20975089]; Natural Science Foundation of Shandong Province of China [Y2007B38]; Chinese Academy of Sciences |
| URL | 查看原文 |
| 收录类别 | SCI |
| 关键词[WOS] | AQUEOUS-SOLUTIONS ; INTRACELLULAR PH ; HEPG2 CELLS ; SENSORS ; ACIDIFICATION ; DERIVATIVES ; DYES ; CA2+ ; EXCITATION ; INHIBITION |
| 文章类型 | Review |
| 语种 | 英语 |
| WOS研究方向 | Chemistry |
| WOS记录号 | WOS:000282542800014 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/3719 |
| 专题 | 中科院海岸带环境过程与生态修复重点实验室_环境化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Rui,Yu, Chunwei,Yu, Fabiao,et al. Molecular fluorescent probes for monitoring pH changes in living cells[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2010,29(9):1004-1013. |
| APA | Wang, Rui,Yu, Chunwei,Yu, Fabiao,&Chen, Lingxin.(2010).Molecular fluorescent probes for monitoring pH changes in living cells.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,29(9),1004-1013. |
| MLA | Wang, Rui,et al."Molecular fluorescent probes for monitoring pH changes in living cells".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 29.9(2010):1004-1013. |
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