Molecular fluorescent probes for monitoring pH changes in living cells
Wang, Rui1; Yu, Chunwei1,2; Yu, Fabiao1; Chen, Lingxin1
2010-10-01
Source PublicationTRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
Volume29Issue:9Pages:1004-1013
Contribution Rank[Wang, Rui; Yu, Chunwei; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yu, Chunwei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
AbstractThe availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.; The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
Corresponding AuthorChen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
KeywordFluorescence Microscopy Fluorescent Probe Intracellular Ph Living Cell Organic Synthesis Ph Detection Ph Indicator Ph Regulation Signal Transduction Small Molecular Probe
Department环境化学实验室 
Subject AreaChemistry, Analytical
Funding OrganizationDepartment of Science and Technology of Shandong Province of China [2008GG20005005]; National Natural Science Foundation of China [20975089]; Natural Science Foundation of Shandong Province of China [Y2007B38]; Chinese Academy of Sciences
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Indexed BySCI
WOS KeywordAQUEOUS-SOLUTIONS ; INTRACELLULAR PH ; HEPG2 CELLS ; SENSORS ; ACIDIFICATION ; DERIVATIVES ; DYES ; CA2+ ; EXCITATION ; INHIBITION
SubtypeReview
Language英语
WOS Research AreaChemistry
WOS IDWOS:000282542800014
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/3719
Collection中科院海岸带环境过程与生态修复重点实验室_环境化学实验室
Affiliation1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Wang, Rui,Yu, Chunwei,Yu, Fabiao,et al. Molecular fluorescent probes for monitoring pH changes in living cells[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2010,29(9):1004-1013.
APA Wang, Rui,Yu, Chunwei,Yu, Fabiao,&Chen, Lingxin.(2010).Molecular fluorescent probes for monitoring pH changes in living cells.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,29(9),1004-1013.
MLA Wang, Rui,et al."Molecular fluorescent probes for monitoring pH changes in living cells".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 29.9(2010):1004-1013.
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