Molecular fluorescent probes for monitoring pH changes in living cells
Wang, Rui1; Yu, Chunwei1,2; Yu, Fabiao1; Chen, Lingxin1
2010-10-01
发表期刊TRAC-TRENDS IN ANALYTICAL CHEMISTRY
ISSN0165-9936
卷号29期号:9页码:1004-1013
产权排序[Wang, Rui; Yu, Chunwei; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Yu, Chunwei] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
摘要The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.; The availability of synthetic fluorescent probes and the development of powerful new approaches to microscopy have made fluorescence microscopy an essential tool for biomedical science and biology. Intracellular pH plays vital roles in physiological and pathological processes (e.g., receptor-mediated signal transduction, cell growth and apoptosis, ion transport, and homeostasis). Due to the presence of an H+ acceptor linked to the fluorophore, some small molecular fluorescent probes display pH-sensitive absorption and fluorescence emission. Such behavior has been employed to engineer pH indicators for studies of pH regulation in vivo. The review summarizes advances in the creation of novel molecular fluorescent pH probes and their applications in biomedicine and cell biology, especially focusing on the design and the synthesis of small molecular probes for monitoring pH changes in living cells. (C) 2010 Elsevier Ltd. All rights reserved.
通讯作者Chen, LX, Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
关键词Fluorescence Microscopy Fluorescent Probe Intracellular Ph Living Cell Organic Synthesis Ph Detection Ph Indicator Ph Regulation Signal Transduction Small Molecular Probe
作者部门环境化学实验室 
学科领域Chemistry, Analytical
项目资助者Department of Science and Technology of Shandong Province of China [2008GG20005005]; National Natural Science Foundation of China [20975089]; Natural Science Foundation of Shandong Province of China [Y2007B38]; Chinese Academy of Sciences
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收录类别SCI
关键词[WOS]AQUEOUS-SOLUTIONS ; INTRACELLULAR PH ; HEPG2 CELLS ; SENSORS ; ACIDIFICATION ; DERIVATIVES ; DYES ; CA2+ ; EXCITATION ; INHIBITION
文章类型Review
语种英语
WOS研究方向Chemistry
WOS记录号WOS:000282542800014
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文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/3719
专题中科院海岸带环境过程与生态修复重点实验室_环境化学实验室
作者单位1.Chinese Acad Sci, Key Lab Coastal Environm Proc, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
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Wang, Rui,Yu, Chunwei,Yu, Fabiao,et al. Molecular fluorescent probes for monitoring pH changes in living cells[J]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY,2010,29(9):1004-1013.
APA Wang, Rui,Yu, Chunwei,Yu, Fabiao,&Chen, Lingxin.(2010).Molecular fluorescent probes for monitoring pH changes in living cells.TRAC-TRENDS IN ANALYTICAL CHEMISTRY,29(9),1004-1013.
MLA Wang, Rui,et al."Molecular fluorescent probes for monitoring pH changes in living cells".TRAC-TRENDS IN ANALYTICAL CHEMISTRY 29.9(2010):1004-1013.
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