Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
| Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems | |
Ji, Yunxia1,2; Wang, Yunqing1 ; Wang, Xiaoyan5; Lv, Changjun2; Zhou, Qunfang4; Jiang, Guibin4; Yan, Bing3; Chen, Lingxin1
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| Source Publication | JOURNAL OF HAZARDOUS MATERIALS
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| ISSN | 0304-3894 |
| 2024-04-15 | |
| Volume | 468Pages:21 |
| Keyword | Complex interaction Toxic effect Nanoparticle Physiological system Biological system |
| DOI | 10.1016/j.jhazmat.2024.133800 |
| Corresponding Author | Yan, Bing(drbingyan@yahoo.com) ; Chen, Lingxin(lxchen@yic.ac.cn) |
| Abstract | The exploration of nanoparticle applications is filled with promise, but their impact on the environment and human health raises growing concerns. These tiny environmental particles can enter the human body through various routes, such as the respiratory system, digestive tract, skin absorption, intravenous injection, and implantation. Once inside, they can travel to distant organs via the bloodstream and lymphatic system. This journey often results in nanoparticles adhering to cell surfaces and being internalized. Upon entering cells, nanoparticles can provoke significant structural and functional changes. They can potentially disrupt critical cellular processes, including damaging cell membranes and cytoskeletons, impairing mitochondrial function, altering nuclear structures, and inhibiting ion channels. These disruptions can lead to widespread alterations by interfering with complex cellular signaling pathways, potentially causing cellular, organ, and systemic impairments. This article delves into the factors influencing how nanoparticles behave in biological systems. These factors include the nanoparticles' size, shape, charge, and chemical composition, as well as the characteristics of the cells and their surrounding environment. It also provides an overview of the impact of nanoparticles on cells, organs, and physiological systems and discusses possible mechanisms behind these adverse effects. Understanding the toxic effects of nanoparticles on physiological systems is crucial for developing safer, more effective nanoparticlebased technologies. |
| Funding Organization | Natural Science Foundation of Shandong Province of China ; Taishan Scholars Program ; Instru-ment Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Pearl River Talent Recruitment Program of Guangdong Province |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | TITANIUM-DIOXIDE NANOPARTICLES ; SILICA NANOPARTICLES ; GOLD NANOPARTICLES ; OXIDATIVE STRESS ; CELLULAR UPTAKE ; SILVER NANOPARTICLES ; PROTEIN CORONA ; GRAPHENE OXIDE ; CRUCIAL ROLE ; IN-VITRO |
| WOS Research Area | Engineering ; Environmental Sciences & Ecology |
| WOS ID | WOS:001200134500001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/35329 |
| Collection | 中国科学院海岸带环境过程与生态修复重点实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心 |
| Corresponding Author | Yan, Bing; Chen, Lingxin |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Binzhou Med Univ, Binzhou Med Univ Hosp, Dept Resp & Crit Care Med, Binzhou 256603, Peoples R China 3.Guangzhou Univ, Inst Environm Res Greater Bay Area, Key Lab Water Qual & Conservat Pearl River Delta, Minist Educ, Guangzhou 510006, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China |
| Recommended Citation GB/T 7714 | Ji, Yunxia,Wang, Yunqing,Wang, Xiaoyan,et al. Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,468:21. |
| APA | Ji, Yunxia.,Wang, Yunqing.,Wang, Xiaoyan.,Lv, Changjun.,Zhou, Qunfang.,...&Chen, Lingxin.(2024).Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems.JOURNAL OF HAZARDOUS MATERIALS,468,21. |
| MLA | Ji, Yunxia,et al."Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems".JOURNAL OF HAZARDOUS MATERIALS 468(2024):21. |
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