Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems

doi:10.1016/j.jhazmat.2024.133800

	Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems
	Ji, Yunxia 1,2; Wang, Yunqing1 ; Wang, Xiaoyan 5; Lv, Changjun 2; Zhou, Qunfang 4; Jiang, Guibin 4; Yan, Bing 3; Chen, Lingxin1
发表期刊	JOURNAL OF HAZARDOUS MATERIALS
ISSN	0304-3894
	2024-04-15
卷号	468 页码:21
关键词	Complex interaction Toxic effect Nanoparticle Physiological system Biological system
DOI	10.1016/j.jhazmat.2024.133800
通讯作者	Yan, Bing(drbingyan@yahoo.com) ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	The exploration of nanoparticle applications is filled with promise, but their impact on the environment and human health raises growing concerns. These tiny environmental particles can enter the human body through various routes, such as the respiratory system, digestive tract, skin absorption, intravenous injection, and implantation. Once inside, they can travel to distant organs via the bloodstream and lymphatic system. This journey often results in nanoparticles adhering to cell surfaces and being internalized. Upon entering cells, nanoparticles can provoke significant structural and functional changes. They can potentially disrupt critical cellular processes, including damaging cell membranes and cytoskeletons, impairing mitochondrial function, altering nuclear structures, and inhibiting ion channels. These disruptions can lead to widespread alterations by interfering with complex cellular signaling pathways, potentially causing cellular, organ, and systemic impairments. This article delves into the factors influencing how nanoparticles behave in biological systems. These factors include the nanoparticles' size, shape, charge, and chemical composition, as well as the characteristics of the cells and their surrounding environment. It also provides an overview of the impact of nanoparticles on cells, organs, and physiological systems and discusses possible mechanisms behind these adverse effects. Understanding the toxic effects of nanoparticles on physiological systems is crucial for developing safer, more effective nanoparticlebased technologies.
资助机构	Natural Science Foundation of Shandong Province of China ; Taishan Scholars Program ; Instru-ment Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding ; Pearl River Talent Recruitment Program of Guangdong Province
收录类别	SCI
语种	英语
关键词[WOS]	TITANIUM-DIOXIDE NANOPARTICLES ; SILICA NANOPARTICLES ; GOLD NANOPARTICLES ; OXIDATIVE STRESS ; CELLULAR UPTAKE ; SILVER NANOPARTICLES ; PROTEIN CORONA ; GRAPHENE OXIDE ; CRUCIAL ROLE ; IN-VITRO
研究领域[WOS]	Engineering ; Environmental Sciences & Ecology
WOS记录号	WOS:001200134500001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/35329
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Yan, Bing; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Binzhou Med Univ, Binzhou Med Univ Hosp, Dept Resp & Crit Care Med, Binzhou 256603, Peoples R China 3.Guangzhou Univ, Inst Environm Res Greater Bay Area, Key Lab Water Qual & Conservat Pearl River Delta, Minist Educ, Guangzhou 510006, Peoples R China 4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Ji, Yunxia,Wang, Yunqing,Wang, Xiaoyan,et al. Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,468:21.
APA	Ji, Yunxia.,Wang, Yunqing.,Wang, Xiaoyan.,Lv, Changjun.,Zhou, Qunfang.,...&Chen, Lingxin.(2024).Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems.JOURNAL OF HAZARDOUS MATERIALS,468,21.
MLA	Ji, Yunxia,et al."Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems".JOURNAL OF HAZARDOUS MATERIALS 468(2024):21.