Molecularly imprinted metal-organic frameworks assisted cloth and paper hybrid microfluidic devices for visual detection of gonyautoxin
Xiang, Jiawen1,2; Qi, Ji1,6; Hu, Die1,3; Wang, Chao1,4; Wang, Liyan1; Wu, Yixuan1; Chen, Jiadong6; Zhang, Zhiyang1,2; Wang, Xiaoyan5; Li, Bowei1,2; Chen, Lingxin1,2
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
2024-05-05
Volume469Pages:10
KeywordGonyautoxin 1/4 Colorimetric sensor Microfluidic device Molecularly imprinted polymer
DOI10.1016/j.jhazmat.2024.133969
Corresponding AuthorLi, Bowei(bwli@yic.ac.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
AbstractMarine algal toxin contamination is a major threat to human health. Thus, it is crucial to develop rapid and onsite techniques for detecting algal toxins. In this work, we developed colorimetric cloth and paper hybrid microfluidic devices (mu CPADs) for rapid detection of gonyautoxin (GTX1/4) combined with molecularly imprinted polymers. In addition, the metal -organic frameworks (MOFs) composites were applied for this approach by their unique features. Guanosine serves as a dummy template for surface imprinting and has certain structural advantages in recognizing gonyautoxin. MOF@MIPs composites were able to perform a catalytic color reaction using hydrogen peroxide-tetramethylbenzidine for the detection of GTX1/4. The cloth -based sensing substrates were assembled on origami mu PADs to form user-friendly, miniaturized colorimetric mu CPADs. Combined with a smartphone, the proposed colorimetric mu CPADs successfully achieved a low limit of detection of 0.65 mu g/L within the range of 1-200 mu g/L for rapid visual detection of GTX1/4. Moreover, the GTX1/4 of real shellfish and seawater samples were satisfactorily detected to indicate the application prospect of the mu CPADs. The proposed method shows good potential in the low-cost, stable establishment of assays for the rapid detection of environmental biotoxins.
Funding OrganizationNational Natural Science Foundation of China Major Scientific Research Instrument Development Project ; National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation Key Project of China ; Open Fund Project of Key Laboratory of Ocean Observation Technology
Indexed BySCI
Language英语
WOS KeywordPERFORMANCE LIQUID-CHROMATOGRAPHY ; APTAMER ; DESIGN ; TOXINS ; SENSOR
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS IDWOS:001202721600001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/35311
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Corresponding AuthorLi, Bowei; Chen, Lingxin
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China
4.Harbin Inst Technol Weihai, Dept Appl Chem, Weihai 264209, Peoples R China
5.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
6.Chung Ang Univ, Dept Chem, Seoul 06974, South Korea
Recommended Citation
GB/T 7714
Xiang, Jiawen,Qi, Ji,Hu, Die,et al. Molecularly imprinted metal-organic frameworks assisted cloth and paper hybrid microfluidic devices for visual detection of gonyautoxin[J]. JOURNAL OF HAZARDOUS MATERIALS,2024,469:10.
APA Xiang, Jiawen.,Qi, Ji.,Hu, Die.,Wang, Chao.,Wang, Liyan.,...&Chen, Lingxin.(2024).Molecularly imprinted metal-organic frameworks assisted cloth and paper hybrid microfluidic devices for visual detection of gonyautoxin.JOURNAL OF HAZARDOUS MATERIALS,469,10.
MLA Xiang, Jiawen,et al."Molecularly imprinted metal-organic frameworks assisted cloth and paper hybrid microfluidic devices for visual detection of gonyautoxin".JOURNAL OF HAZARDOUS MATERIALS 469(2024):10.
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