Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice

doi:10.3390/jmse9050505

YIC-IR

	Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice
	Yuan, Jingyi 1,2; Qin, Song1,3 ; Li, Wenjun1,3 ; Zhang, Yubing 1,2; Wang, Yuting 1; Chang, Xiulian 2; Li, Lili1,3
发表期刊	JOURNAL OF MARINE SCIENCE AND ENGINEERING
	2021-05-01
卷号	9 期号:5 页码:13
关键词	fucoidan microbiome metabolomics gut microbiota
DOI	10.3390/jmse9050505
通讯作者	Li, Lili(llli@yic.ac.cn)
英文摘要	Fucoidan is a kind of polysaccharide with antitumor and antioxidant properties, which is mainly isolated from brown algae. Although there are many reports about the prebiotic effects of polysaccharides on hosts, there are few reports about the effects of fucoidan on blood biochemical indexes, intestinal microbiome, and metabolic function on healthy hosts. We applied 16S rRNA gene amplicon sequencing and LC-MS/MS metabolomics to evaluate the changes in the gut microbiome and metabolite profiles of fucoidan treatment in mice over 10 weeks. Fucoidan treatment modulated lipid metabolism, including significantly decreasing serum triglyceride level in healthy mice. Fucoidan also significantly inhibited serum lipopolysaccharide-binding protein (LBP) concentration, a biomarker of endotoxemia. Correlation analysis further showed that Lactobacillus animalis populations that were enriched by fucoidan demonstrated significantly negative correlations with serum triglyceride level. The abundance of Lactobacillus gasseri and Lactobacillus reuteri, increased by fucoidan supplementation, demonstrated significantly negative correlation with lipopolysaccharide-binding protein levels. Lactobacillus gasseri also demonstrated significantly positive correlations with three tryptophan-related metabolites, including indoleacrylic acid, 3-indoleacrylic acid, and 5-hydroxytryptamine, which were all increased by fucoidan administration. Combined with the previous evidence, the results indicate that fucoidan exerts prebiotic effects, such as lipid metabolism suppression and metabolic endotoxemia suppression, by modulating the abundance of gut microbiota, such as Lactobacillus animalis, Lactobacillus gasseri, and Lactobacillus reuteri, as well as microbiota-dependent metabolites, such as tryptophan-related metabolites.
资助机构	Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Science and Technology Program of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	GUT MICROBIOTA ; INFLAMMATORY RESPONSE ; VISCERAL FAT ; PROTECTS ; SUPPRESSES
研究领域[WOS]	Engineering ; Oceanography
WOS记录号	WOS:000662447900001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/34777
专题	中国科学院烟台海岸带研究所
通讯作者	Li, Lili
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Jingyi,Qin, Song,Li, Wenjun,et al. Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice[J]. JOURNAL OF MARINE SCIENCE AND ENGINEERING,2021,9(5):13.
APA	Yuan, Jingyi.,Qin, Song.,Li, Wenjun.,Zhang, Yubing.,Wang, Yuting.,...&Li, Lili.(2021).Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice.JOURNAL OF MARINE SCIENCE AND ENGINEERING,9(5),13.
MLA	Yuan, Jingyi,et al."Microbiome-Metabolomics Reveals Prebiotic Benefits of Fucoidan Supplementation in Mice".JOURNAL OF MARINE SCIENCE AND ENGINEERING 9.5(2021):13.