Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency
Zhang, Jiajing1,2,3; Yuan, Xiaoqian3; Li, Hongsen3; Yu, Liting3; Zhang, Yulong3; Pang, Keyi3; Sun, Chaoyue3; Liu, Zhongyang3; Li, Jie3; Ma, Liying3; Song, Jinming1,4; Chen, Lingxin2,3
Source PublicationRSC ADVANCES
2024-01-17
Volume14Issue:5Pages:3122-3134
DOI10.1039/d3ra07743h
Corresponding AuthorMa, Liying() ; Chen, Lingxin(lxchen@yic.ac.cn)
AbstractBacterial infections from chronic wounds affect about 175 million people each year and are a significant clinical problem. Through the integration of photodynamic therapy (PDT) and chemotherapy, a new photosensitizer consisting of ammonium salt N,N-bis-(2-hydroxyethyl)-N-(6-(4-(10,15,20-trimesitylporphyrin-5-yl) phenoxy) hexane)-N-methanaminium bromide, TMP(+) was successfully synthesized with a total reaction yield of 10%. The novel photosensitizer consists of two parts, a porphyrin photosensitizer part and a quaternary ammonium salt part, to achieve the synergistic effect of photodynamic and chemical antibacterial activity. With the increase of TMP(+) concentration, the diameter of the PCT fiber membranes (POL/COL/TMP(+); POL, polycaprolactone; COL, collagen) gradually increased, which was caused by the charge of the quaternary ammonium salt. At the same time, the antibacterial properties were gradually improved. We finally selected the PCT 0.5% group for the antibacterial experiment, with excellent performance in fiber uniformity, hydrophobicity and biosafety. The antibacterial experiment showed that the modified porphyrin TMP(+) had a better antibacterial effect than others. In vivo chronic wound healing experiments proved that the antibacterial and anti-inflammatory effect of the PCTL group was the best, further confirmed by H&E histological analysis, immunofluorescence and immunohistochemistry mechanism experiments. This research lays the foundation for the manufacture of novel molecules that combine chemical and photodynamic strategies. A new photosensitizer consisting of ammonium salt, TMP(+) was synthesized and achieved the synergistic effect of photodynamic and chemical antibacterial activity. Experiments showed promising bactericidal properties, while accelerating the healing of Staphylococcus aureus infected mice.
Funding OrganizationNational Natural Science Foundation of China ; Foundation of Binzhou Medical University
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS IDWOS:001144849200001
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/34342
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Corresponding AuthorMa, Liying; Chen, Lingxin
Affiliation1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jiajing,Yuan, Xiaoqian,Li, Hongsen,et al. Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency[J]. RSC ADVANCES,2024,14(5):3122-3134.
APA Zhang, Jiajing.,Yuan, Xiaoqian.,Li, Hongsen.,Yu, Liting.,Zhang, Yulong.,...&Chen, Lingxin.(2024).Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency.RSC ADVANCES,14(5),3122-3134.
MLA Zhang, Jiajing,et al."Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency".RSC ADVANCES 14.5(2024):3122-3134.
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