Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency

doi:10.1039/d3ra07743h

	Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency
	Zhang, Jiajing 1,2,3; Yuan, Xiaoqian 3; Li, Hongsen 3; Yu, Liting 3; Zhang, Yulong 3; Pang, Keyi 3; Sun, Chaoyue 3; Liu, Zhongyang 3; Li, Jie3 ; Ma, Liying 3; Song, Jinming 1,4; Chen, Lingxin2,3
发表期刊	RSC ADVANCES
	2024-01-17
卷号	14 期号:5 页码:3122-3134
DOI	10.1039/d3ra07743h
通讯作者	Ma, Liying() ; Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Bacterial infections from chronic wounds affect about 175 million people each year and are a significant clinical problem. Through the integration of photodynamic therapy (PDT) and chemotherapy, a new photosensitizer consisting of ammonium salt N,N-bis-(2-hydroxyethyl)-N-(6-(4-(10,15,20-trimesitylporphyrin-5-yl) phenoxy) hexane)-N-methanaminium bromide, TMP(+) was successfully synthesized with a total reaction yield of 10%. The novel photosensitizer consists of two parts, a porphyrin photosensitizer part and a quaternary ammonium salt part, to achieve the synergistic effect of photodynamic and chemical antibacterial activity. With the increase of TMP(+) concentration, the diameter of the PCT fiber membranes (POL/COL/TMP(+); POL, polycaprolactone; COL, collagen) gradually increased, which was caused by the charge of the quaternary ammonium salt. At the same time, the antibacterial properties were gradually improved. We finally selected the PCT 0.5% group for the antibacterial experiment, with excellent performance in fiber uniformity, hydrophobicity and biosafety. The antibacterial experiment showed that the modified porphyrin TMP(+) had a better antibacterial effect than others. In vivo chronic wound healing experiments proved that the antibacterial and anti-inflammatory effect of the PCTL group was the best, further confirmed by H&E histological analysis, immunofluorescence and immunohistochemistry mechanism experiments. This research lays the foundation for the manufacture of novel molecules that combine chemical and photodynamic strategies. A new photosensitizer consisting of ammonium salt, TMP(+) was synthesized and achieved the synergistic effect of photodynamic and chemical antibacterial activity. Experiments showed promising bactericidal properties, while accelerating the healing of Staphylococcus aureus infected mice.
资助机构	National Natural Science Foundation of China ; Foundation of Binzhou Medical University
收录类别	SCI
语种	英语
研究领域[WOS]	Chemistry
WOS记录号	WOS:001144849200001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/34342
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Ma, Liying; Chen, Lingxin
作者单位	1.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Marine Ecol & Environm Sci, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jiajing,Yuan, Xiaoqian,Li, Hongsen,et al. Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency[J]. RSC ADVANCES,2024,14(5):3122-3134.
APA	Zhang, Jiajing.,Yuan, Xiaoqian.,Li, Hongsen.,Yu, Liting.,Zhang, Yulong.,...&Chen, Lingxin.(2024).Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency.RSC ADVANCES,14(5),3122-3134.
MLA	Zhang, Jiajing,et al."Novel porphyrin derivative containing cations as new photodynamic antimicrobial agent with high efficiency".RSC ADVANCES 14.5(2024):3122-3134.