Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna

doi:10.2139/ssrn.4327486

	Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna
	Huang, Yang 1; Yao, Hongye 1; Li, Xuehua 1; Li, Fei2,3 ; Wang, Xiaoqing2,4 ; Fu, Zhiqiang 1; Li, Ningjing 1; Chen, Jingwen 1
发表期刊	SSRN
ISSN	15565068
	2023
关键词	Detoxification Metabolism Nanostructured materials Proteins Toxicity Transcription
DOI	10.2139/ssrn.4327486
英文摘要	Graphene can be modified with functional groups when released into the environment. However, very little is known about molecular mechanisms of chronic aquatic toxicity induced by graphene nanomaterials with different surface functional groups. By using RNA sequencing, we investigated the toxic mechanisms of unfunctionalized graphene (u-G), carboxylated graphene (G-COOH), aminated graphene (G-NH2), hydroxylated graphene (G-OH) and thiolated graphene (G-SH) to Daphnia magna during 21-day exposure. We revealed that alteration of ferritin transcription levels in the "mineral absorption" signaling pathway is a molecular initiating event leading to potential of oxidative stress in Daphnia magna by u-G, while toxic effects of four functionalized graphenes are related to several metabolic pathways including the "protein digestion and absorption" pathway and "carbohydrate digestion and absorption" pathway. The transcription and translation related pathways were inhibited by G-NH2 and G-OH, which further affected the functions of proteins and normal life activities. Noticeably, detoxifications of graphene and its surface functional derivatives were promoted by increasing the gene expressions related to chitin and glucose metabolism as well as cuticle structure components. These findings demonstrate important mechanistic insights that can potentially be employed for safety assessment of graphene nanomaterials. © 2023, The Authors. All rights reserved.
收录类别	EI
语种	英语
EI主题词	Detoxification ; Metabolism ; Nanostructured materials ; Proteins ; Toxicity ; Transcription
EI入藏号	20230017081
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/34289
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
作者单位	1.Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Linggong Road 2, Dalian; 116024, China; 2.CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research (YIC), Chinese Academy of Sciences (CAS), Shandong Key Laboratory of Coastal Environmental Processes, YICCAS, Yantai; 264003, China; 3.Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao; 266071, China; 4.University of Chinese Academy of Sciences, Beijing; 100049, China
推荐引用方式 GB/T 7714	Huang, Yang,Yao, Hongye,Li, Xuehua,et al. Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna[J]. SSRN,2023.
APA	Huang, Yang.,Yao, Hongye.,Li, Xuehua.,Li, Fei.,Wang, Xiaoqing.,...&Chen, Jingwen.(2023).Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna.SSRN.
MLA	Huang, Yang,et al."Graphene Materials Induce Chronic Aquatic Toxicity Through the Regulation of DNA Damage, Metabolism and Oxidative Stress in Daphnia Magna".SSRN (2023).