The invention relates to functional food and pharmaceutical industries, in particular to glucosamine chondroitin sulfate and a preparation method and application thereof. The structural formula of the glucosamine chondroitin sulfate is shown in formula (1), wherein the average polymerization degree n ranges from 5 to 1000. Said glucosamine chondroitin sulfate salt is obtained by using glucosamine hydrochloride or sulfate or phosphate and sodium chondroitin sulfate through the processes of ion exchange, mixed solution dialysis or mixed solution direct precipitation, The chondroitin sulfate molecular weight is obtained by natural extraction, or fermentation preparation, or degradation, or all polysaccharides conforming to chondroitin sulfate structure obtained by synthetic method. The present invention combines chondroitin sulfate and glucosamine organically, Different from the conventional compound product of the glucosamine chondroitin sulfate and the glucosamine chondroitin sulfate, the glucosamine chondroitin sulfate does not contain small molecular inorganic salts or is low in content; and the prepared glucosamine chondroitin sulfate has a good treatment effect on an osteoarthritis model rat in an oral gastric lavage manner, and can be used for but not limited to joint treatment or auxiliary health care effect. The glucosamine chondroitin sulfate can be widely applied to the fields of functional foods and medicines.
; 谭文强
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