The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)
Wang, Hongdan1,4; Wang, Yunqing1,4; Wang, Qiaoning1,4; Lv, Min1,4; Zhao, Xizhen1,4; Ji, Yunxia3; Han, Xiaoyue1; Wang, Xiaoyan3; Chen, Lingxin1,2,4
Source PublicationJOURNAL OF HAZARDOUS MATERIALS
ISSN0304-3894
2022-10-15
Volume440Pages:10
KeywordMicroplastics Embryonic developmental toxicity Oxidative stress toxicity Cardiotoxicity effects Antagonize toxic effects
DOI10.1016/j.jhazmat.2022.129711
Corresponding AuthorChen, Lingxin(lxchen@yic.ac.cn)
AbstractMicroplastics (MPs) have the characteristics of large specific surface area, high hydrophobicity and surface charge, so they are easy to combine with other pollutants and cause toxic effects on aquatic organisms. Here, we prepared a polyvinyl chloride-microplastics (PVC-MPs) fragmentation model to simulate the real microplastic state, and characterized its composition, morphology, particle size and zeta potential. On this basis, we used single and compound exposure of PVC and di(2-ethylhexyl) phthalate (DEHP) to explore their effects on hatchability and mortality of zebrafish (Danio rerio) embryos and toxicity to oxidative stress and cardiac development in zebrafish larvae. Herein, PVC-MPs slowed down the hatching rate of zebrafish embryos and induced the death of zebrafish, while DEHP could slow down the induced of death, it had no effect on hatching rate. The PVC-MPs/DEHP single pollution could induce the reactive oxygen species (ROS) and activated the antioxidant defense signaling pathway, while the compound group showed the level of feedback autoregulation of NF-E2-related factor 2 (Nrf2) signaling pathway. The single pollution also could inhibit the expression of genes related to cardiac development, while the combined pollution showed an antagonistic effect. This study provided a theoretical basis for the ecotoxicology and biomonitoring of MPs in the natural state.
Funding OrganizationNatural Science Foundation of Shandong Province of China ; National Natural Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding
Indexed BySCI
Language英语
WOS KeywordACCUMULATION ; EXPOSURE ; COASTAL ; WATERS ; GILLS ; DEHP ; FISH
WOS Research AreaEngineering ; Environmental Sciences & Ecology
WOS IDWOS:001043988000006
Citation statistics
Cited Times:28[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/33466
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Corresponding AuthorChen, Lingxin
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai 264003, Peoples R China
2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Wang, Hongdan,Wang, Yunqing,Wang, Qiaoning,et al. The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,440:10.
APA Wang, Hongdan.,Wang, Yunqing.,Wang, Qiaoning.,Lv, Min.,Zhao, Xizhen.,...&Chen, Lingxin.(2022).The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio).JOURNAL OF HAZARDOUS MATERIALS,440,10.
MLA Wang, Hongdan,et al."The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)".JOURNAL OF HAZARDOUS MATERIALS 440(2022):10.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Wang, Hongdan]'s Articles
[Wang, Yunqing]'s Articles
[Wang, Qiaoning]'s Articles
Baidu academic
Similar articles in Baidu academic
[Wang, Hongdan]'s Articles
[Wang, Yunqing]'s Articles
[Wang, Qiaoning]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Wang, Hongdan]'s Articles
[Wang, Yunqing]'s Articles
[Wang, Qiaoning]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.