The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)

doi:10.1016/j.jhazmat.2022.129711

	The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)
	Wang, Hongdan 1,4; Wang, Yunqing1,4 ; Wang, Qiaoning 1,4; Lv, Min1,4 ; Zhao, Xizhen 1,4; Ji, Yunxia 3; Han, Xiaoyue 1; Wang, Xiaoyan 3; Chen, Lingxin1,2,4
发表期刊	JOURNAL OF HAZARDOUS MATERIALS
ISSN	0304-3894
	2022-10-15
卷号	440 页码:10
关键词	Microplastics Embryonic developmental toxicity Oxidative stress toxicity Cardiotoxicity effects Antagonize toxic effects
DOI	10.1016/j.jhazmat.2022.129711
通讯作者	Chen, Lingxin(lxchen@yic.ac.cn)
英文摘要	Microplastics (MPs) have the characteristics of large specific surface area, high hydrophobicity and surface charge, so they are easy to combine with other pollutants and cause toxic effects on aquatic organisms. Here, we prepared a polyvinyl chloride-microplastics (PVC-MPs) fragmentation model to simulate the real microplastic state, and characterized its composition, morphology, particle size and zeta potential. On this basis, we used single and compound exposure of PVC and di(2-ethylhexyl) phthalate (DEHP) to explore their effects on hatchability and mortality of zebrafish (Danio rerio) embryos and toxicity to oxidative stress and cardiac development in zebrafish larvae. Herein, PVC-MPs slowed down the hatching rate of zebrafish embryos and induced the death of zebrafish, while DEHP could slow down the induced of death, it had no effect on hatching rate. The PVC-MPs/DEHP single pollution could induce the reactive oxygen species (ROS) and activated the antioxidant defense signaling pathway, while the compound group showed the level of feedback autoregulation of NF-E2-related factor 2 (Nrf2) signaling pathway. The single pollution also could inhibit the expression of genes related to cardiac development, while the combined pollution showed an antagonistic effect. This study provided a theoretical basis for the ecotoxicology and biomonitoring of MPs in the natural state.
资助机构	Natural Science Foundation of Shandong Province of China ; National Natural Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding
收录类别	SCI
语种	英语
关键词[WOS]	ACCUMULATION ; EXPOSURE ; COASTAL ; WATERS ; GILLS ; DEHP ; FISH
研究领域[WOS]	Engineering ; Environmental Sciences & Ecology
WOS记录号	WOS:001043988000006
引用统计	被引频次：39[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33466
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Chen, Lingxin
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Processes & Ecol Rem, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wang, Hongdan,Wang, Yunqing,Wang, Qiaoning,et al. The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,440:10.
APA	Wang, Hongdan.,Wang, Yunqing.,Wang, Qiaoning.,Lv, Min.,Zhao, Xizhen.,...&Chen, Lingxin.(2022).The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio).JOURNAL OF HAZARDOUS MATERIALS,440,10.
MLA	Wang, Hongdan,et al."The combined toxic effects of polyvinyl chloride microplastics and di (2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio)".JOURNAL OF HAZARDOUS MATERIALS 440(2022):10.