Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol

doi:10.1016/j.foodchem.2023.136886

	Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol
	Yuan, Yuting 1,2,3; Wang, Zhenhua 4; Su, Shengjia 5; Lin, Conghao 4; Mi, Yingqi 1,3; Tan, Wenqiang1,3 ; Guo, Zhanyong1,2,3
发表期刊	FOOD CHEMISTRY
ISSN	0308-8146
	2023-12-15
卷号	429 页码:11
关键词	Amphiphilic low molecular weight chitosan derivative Photostability Self-assembled cationic micelle Solubility Sustained release behavior & alpha -tocopherol
DOI	10.1016/j.foodchem.2023.136886
通讯作者	Tan, Wenqiang(wqtan@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	New amphiphilic low molecular weight chitosan-graft-nicotinic acid bearing decyl groups (LCND) was synthesized by two-step reaction and spontaneously assembled into cationic micelle by ultra-sonication method to improve water solubility and photostability properties of a-tocopherol. The chemical structure of LCND was characterized and physical properties of cationic micelle were evaluated. Results displayed that cationic micelle exhibited strong self-assemble ability with nanoscale spherical morphology and showed best loading ability with loading content of 18.50% when the feeding ratio of LCND to a-tocopherol reached 10:3. Meanwhile, the greatly enhanced water solubility, photostability and sustained release behavior of a-tocopherol in cationic micelle were observed. The cumulative release of a-tocopherol in cationic micelle reached up 82.18% within 96 h while free a-tocopherol was completely released within 10 h. Additionally, release kinetics models were also fitted. The LCND cationic micelle could be promising nanocarrier for improving the physicochemical properties of a-tocopherol in food fields.
资助机构	Youth Innovation Promotion Association CAS, China ; Shandong Key Ramp;D plan, Major Scientific and Technological Innovation Project ; Science amp; Technology Specific Projects in Agricultural High-tech Industrial Demonstration Area of the Yellow River Delta
收录类别	SCI
语种	英语
关键词[WOS]	ALPHA-TOCOPHEROL ; PHOTOSTABILITY ; NANOPARTICLES ; ENCAPSULATION ; DERIVATIVES ; DELIVERY
研究领域[WOS]	Chemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS记录号	WOS:001050470800001
引用统计	被引频次：2[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33451
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Tan, Wenqiang; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 4.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 5.Shandong Saline Alkali Land Modern Agr Co, Dongying 257300, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Yuting,Wang, Zhenhua,Su, Shengjia,et al. Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol[J]. FOOD CHEMISTRY,2023,429:11.
APA	Yuan, Yuting.,Wang, Zhenhua.,Su, Shengjia.,Lin, Conghao.,Mi, Yingqi.,...&Guo, Zhanyong.(2023).Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol.FOOD CHEMISTRY,429,11.
MLA	Yuan, Yuting,et al."Self-assembled low molecular weight chitosan-based cationic micelle for improved water solubility, stability and sustained release of & alpha;-tocopherol".FOOD CHEMISTRY 429(2023):11.