Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase
Chai, Peijun1; Geng, Xuhui2; Zhu, Ruirui1; Wu, Wenpu1; Wang, Xuesong1; Li, Jinhua3; Fu, Longwen3; Wang, Hongdan3; Liu, Wanhui1; Chen, Lingxin3,4; Song, Zhihua1
KeywordCarbon dots Molecularly imprinted polymer Silica microbeads Liquid chromatographic stationary phases Separation performances evaluation
Corresponding AuthorLiu, Wanhui(liuwanhui01@163.com) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Song, Zhihua(zhihuasong08@yeah.net)
AbstractFacing the difficulties in chromatographic separation of polar compounds, this investigation devotes to developing novel stationary phase. Molecularly imprinted polymers (MIPs) have aroused wide attention, owing to their outstanding selectivity, high stability, and low cost. In this work, a novel stationary phase based on carbon dots (CDs), MIP layer, and silica beads was synthesized to exploit high selectivity of MIPs, excellent physicochemical property of CDs, and outstanding chromatographic performances of silica microspheres simultaneously. The MIP doped CDs coated silica (MIP-CDs/SiO2) stationary phase was systematically characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) surface area measurement, and carbon elemental analysis. Furthermore, the chromatographic performance of the MIP-CDs/SiO2 column was thoroughly assessed by using a wide variety of compounds (including nucleosides, sulfonamides, benzoic acids, and some other antibiotics). Meanwhile, the separation efficiency of the MIP-CDs/SiO2 stationary phase was superior to other kinds of stationary phases (e.g. nonimprinted NIP-CDs/SiO2, MIP/SiO2, and C18-SiO2). The results demonstrated that MIP-CDs/SiO2 column exhibited best performance in terms of chromatographic separation. For all tested compounds, the resolution value was not less than 1.60, and the column efficiency of MIP-CDs/SiO2 for thymidine was 22,740 plates/m. The results further indicate that the MIP-CDs/SiO2 column can combine the good properties of MIP, CDs, with those of silica microbeads. Therefore, the developed MIP-CDs/SiO2 stationary phase can be applied in the separation science and chromatography-based techniques.
Funding OrganizationScience and Technology Innovation Development Plan of Yantai City of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Natural Science Foundation of Shandong Province of China ; National Natural Science Foundation of China ; Yantai University Student Innovation and Entrepreneurship Training Program ; National Demonstration Center for Experimental Pharmacy Education (Yantai University)
Indexed BySCI
WOS Research AreaChemistry
WOS IDWOS:001044667600001
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Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLiu, Wanhui; Chen, Lingxin; Song, Zhihua
Affiliation1.Yantai Univ, Univ Shandong, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat,Min, Yantai 264005, Peoples R China
2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Key Lab Deep sea Composit Detect Technol Liaoning, 457 Zhongshan Rd, Dalian 116023, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
4.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Chai, Peijun,Geng, Xuhui,Zhu, Ruirui,et al. Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase[J]. ANALYTICA CHIMICA ACTA,2023,1275:10.
APA Chai, Peijun.,Geng, Xuhui.,Zhu, Ruirui.,Wu, Wenpu.,Wang, Xuesong.,...&Song, Zhihua.(2023).Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase.ANALYTICA CHIMICA ACTA,1275,10.
MLA Chai, Peijun,et al."Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase".ANALYTICA CHIMICA ACTA 1275(2023):10.
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