Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase

doi:10.1016/j.aca.2023.341611

	Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase
	Chai, Peijun 1; Geng, Xuhui 2; Zhu, Ruirui 1; Wu, Wenpu 1; Wang, Xuesong 1; Li, Jinhua3 ; Fu, Longwen3 ; Wang, Hongdan 3; Liu, Wanhui 1; Chen, Lingxin3,4 ; Song, Zhihua 1
发表期刊	ANALYTICA CHIMICA ACTA
ISSN	0003-2670
	2023-09-22
卷号	1275 页码:10
关键词	Carbon dots Molecularly imprinted polymer Silica microbeads Liquid chromatographic stationary phases Separation performances evaluation
DOI	10.1016/j.aca.2023.341611
通讯作者	Liu, Wanhui(liuwanhui01@163.com) ; Chen, Lingxin(lxchen@yic.ac.cn) ; Song, Zhihua(zhihuasong08@yeah.net)
英文摘要	Facing the difficulties in chromatographic separation of polar compounds, this investigation devotes to developing novel stationary phase. Molecularly imprinted polymers (MIPs) have aroused wide attention, owing to their outstanding selectivity, high stability, and low cost. In this work, a novel stationary phase based on carbon dots (CDs), MIP layer, and silica beads was synthesized to exploit high selectivity of MIPs, excellent physicochemical property of CDs, and outstanding chromatographic performances of silica microspheres simultaneously. The MIP doped CDs coated silica (MIP-CDs/SiO2) stationary phase was systematically characterized by scanning electron microscopy (SEM), Brunauer-Emmett-Teller (BET) surface area measurement, and carbon elemental analysis. Furthermore, the chromatographic performance of the MIP-CDs/SiO2 column was thoroughly assessed by using a wide variety of compounds (including nucleosides, sulfonamides, benzoic acids, and some other antibiotics). Meanwhile, the separation efficiency of the MIP-CDs/SiO2 stationary phase was superior to other kinds of stationary phases (e.g. nonimprinted NIP-CDs/SiO2, MIP/SiO2, and C18-SiO2). The results demonstrated that MIP-CDs/SiO2 column exhibited best performance in terms of chromatographic separation. For all tested compounds, the resolution value was not less than 1.60, and the column efficiency of MIP-CDs/SiO2 for thymidine was 22,740 plates/m. The results further indicate that the MIP-CDs/SiO2 column can combine the good properties of MIP, CDs, with those of silica microbeads. Therefore, the developed MIP-CDs/SiO2 stationary phase can be applied in the separation science and chromatography-based techniques.
资助机构	Science and Technology Innovation Development Plan of Yantai City of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; Natural Science Foundation of Shandong Province of China ; National Natural Science Foundation of China ; Yantai University Student Innovation and Entrepreneurship Training Program ; National Demonstration Center for Experimental Pharmacy Education (Yantai University)
收录类别	SCI
语种	英语
关键词[WOS]	EXTRACTION
研究领域[WOS]	Chemistry
WOS记录号	WOS:001044667600001
引用统计	被引频次：1[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33427
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Liu, Wanhui; Chen, Lingxin; Song, Zhihua
作者单位	1.Yantai Univ, Univ Shandong, Collaborat Innovat Ctr Adv Drug Delivery Syst & Bi, Sch Pharm,Key Lab Mol Pharmacol & Drug Evaluat,Min, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, CAS Key Lab Separat Sci Analyt Chem, Key Lab Deep sea Composit Detect Technol Liaoning, 457 Zhongshan Rd, Dalian 116023, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 4.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Chai, Peijun,Geng, Xuhui,Zhu, Ruirui,et al. Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase[J]. ANALYTICA CHIMICA ACTA,2023,1275:10.
APA	Chai, Peijun.,Geng, Xuhui.,Zhu, Ruirui.,Wu, Wenpu.,Wang, Xuesong.,...&Song, Zhihua.(2023).Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase.ANALYTICA CHIMICA ACTA,1275,10.
MLA	Chai, Peijun,et al."Fabrication and application of molecularly imprinted polymer doped carbon dots coated silica stationary phase".ANALYTICA CHIMICA ACTA 1275(2023):10.