Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption

doi:10.1021/acs.est.3c06910

	Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption
	Dong, Fengfeng 1; Pan, Yitao 1; Zhang, Jian 2; Hu, Jianglin 1; Luo, Yi 2; Tang, Jianhui2 ; Dai, Jiayin 1; Sheng, Nan 1
发表期刊	ENVIRONMENTAL SCIENCE & TECHNOLOGY
ISSN	0013-936X
	2023-11-06
卷号	57 期号:48 页码:19442-19452
关键词	PFECA estimated daily intake dietaryexposure cereal exposure pathway
DOI	10.1021/acs.est.3c06910
通讯作者	Sheng, Nan(shengnan@sjtu.edu.cn)
英文摘要	With the replacement of perfluorooctanoic acid (PFOA) with perfluorinated ether carboxylic acids (PFECAs), residents living near fluorochemical industrial parks (FIPs) are exposed to various novel PFECAs. Despite expectations of low accumulation, short-chain PFECAs, such as perfluoro-2-methoxyacetic acid (PFMOAA), previously displayed a considerably high body burden, although the main exposure routes and health risks remain uncertain. Here, we explored the distribution of perfluoroalkyl and polyfluoroalkyl substances (PFASs) in diverse environmental media surrounding a FIP in Shandong Province, China. PFECAs were found at elevated concentrations in all tested matrices, including vegetables, cereals, air, and dust. Among residents, 99.3% of the Sigma(36)PFAS exposure, with a 43.9% contribution from PFECAs, was due to gastrointestinal uptake. Dermal and respiratory exposures were negligible at 0.1 and 0.6%, respectively. The estimated daily intake (EDI) of PFMOAA reached 114.0 ng/kg body weight (bw)/day, ranking first among all detected PFECAs. Cereals emerged as the dominant contributor to PFMOAA body burden, representing over 80% of the overall EDI. The median EDI of hexafluoropropylene oxide dimer acid (HFPO-DA) was 17.9 ng/kg bw/day, markedly higher than the USEPA reference doses (3.0 ng/kg bw/day). The absence of established threshold values for other PFECAs constrains a comprehensive risk assessment.
资助机构	National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Natural Science Foundation of China ; Shanghai Rising-Star Program ; Young Scholar Scientific Research Foundation of National Institute of Environmental Health, China CDC
收录类别	SCI
语种	英语
关键词[WOS]	POLYFLUOROALKYL SUBSTANCES PFASS ; CROP BIOACCUMULATION ; DRINKING-WATER ; LEGACY ; CHAIN ; PLANT ; IDENTIFICATION ; ALTERNATIVES ; ATMOSPHERE ; PFESAS
研究领域[WOS]	Engineering ; Environmental Sciences & Ecology
WOS记录号	WOS:001114495800001
引用统计
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/33187
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室
通讯作者	Sheng, Nan
作者单位	1.Shanghai Jiao Tong Univ, Sch Environm Sci & Engn, State Environm Protect Key Lab Environm Hlth Impac, Shanghai 200240, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Dong, Fengfeng,Pan, Yitao,Zhang, Jian,et al. Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2023,57(48):19442-19452.
APA	Dong, Fengfeng.,Pan, Yitao.,Zhang, Jian.,Hu, Jianglin.,Luo, Yi.,...&Sheng, Nan.(2023).Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption.ENVIRONMENTAL SCIENCE & TECHNOLOGY,57(48),19442-19452.
MLA	Dong, Fengfeng,et al."Comprehensive Assessment of Exposure Pathways for Perfluoroalkyl Ether Carboxylic Acids (PFECAs) in Residents Near a Fluorochemical Industrial Park: The Unanticipated Role of Cereal Consumption".ENVIRONMENTAL SCIENCE & TECHNOLOGY 57.48(2023):19442-19452.