Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
Potentiometric sensor based on a computationally designed molecularly imprinted receptor | |
Cui, Guohua1; Liang, Rongning1; Qin, Wei1,2,3 | |
发表期刊 | ANALYTICA CHIMICA ACTA |
ISSN | 0003-2670 |
2023-01-25 | |
卷号 | 1239页码:9 |
关键词 | Potentiometry Ion -selective electrode Molecularly imprinted polymer Computer -aided design Sulfadiazine |
DOI | 10.1016/j.aca.2022.340720 |
通讯作者 | Liang, Rongning(rnliang@yic.ac.cn) ; Qin, Wei(wqin@yic.ac.cn) |
英文摘要 | Molecularly imprinted polymer (MIP)-based polymeric membrane potentiometric sensors are ideal candidates for detection of organic species. The development of such sensors has opened new attractive horizons for potentiometric sensing. However, it should be noted that in the preparation of these MIP receptors, the selection of the functional monomer usually depends on empirical trial-and error-based optimization, which involves tedious and time-consuming experiments. In this work, the computer-aided design and synthesis of an MIP re-ceptor are applied in the fabrication of an MIP-based potentiometric sensor. The density functional theory calculation with the B3LYP model and 6-31G(d) basis set is used to study the interactions between the functional monomer and template molecules. The binding energies of the complexations between the template molecule and different functional monomers are used as a criterion for the selection of the proper monomer. The designed MIP is then synthesized and employed as the receptor for the fabrication of the potentiometric sensor. As a proof -of-concept experiment, the antibiotic sulfadiazine has been selected as a model and 4 functional monomers, 2-hydroxyethyl methacrylate, methyl methacrylate, N-isopropylacrylamide and N-phenylacrylamide, have been chosen. The designed MIP-based sensor exhibits excellent sensitivity with a linear range of 1-10 mu M and also shows a good selectivity. We believe that the proposed computer-aided synthesis technique for the MIP receptor selection can provide a general and facile way to replace the traditional empirical MIP preparation method in the fabrication of MIP-based electrochemical and optical sensors. |
资助机构 | National Natural Science Foundation of China ; Key Deployment Project of Centre for Ocean Mega -Research of Science, Chinese Academy of Sciences ; Youth Innovation Promotion Association of CAS ; Taishan Scholar Program of Shandong Province |
收录类别 | SCI |
语种 | 英语 |
关键词[WOS] | ION-SELECTIVE ELECTRODES ; POLYMER |
研究领域[WOS] | Chemistry |
WOS记录号 | WOS:000904960100009 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/32477 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 |
通讯作者 | Liang, Rongning; Qin, Wei |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Shandong, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China |
推荐引用方式 GB/T 7714 | Cui, Guohua,Liang, Rongning,Qin, Wei. Potentiometric sensor based on a computationally designed molecularly imprinted receptor[J]. ANALYTICA CHIMICA ACTA,2023,1239:9. |
APA | Cui, Guohua,Liang, Rongning,&Qin, Wei.(2023).Potentiometric sensor based on a computationally designed molecularly imprinted receptor.ANALYTICA CHIMICA ACTA,1239,9. |
MLA | Cui, Guohua,et al."Potentiometric sensor based on a computationally designed molecularly imprinted receptor".ANALYTICA CHIMICA ACTA 1239(2023):9. |
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