Highly Sensitive and Reliable Internal-Standard Surface-Enhanced Raman Scattering Microneedles for Determination of Bacterial Metabolites as Infection Biomarkers in Skin Interstitial Fluid
Mei, Rongchao1,2,3; Wang, Yunqing2; Shi, Shang2; Zhao, Xizhen2; Zhang, Zhiyang2; Wang, Xiaoyan3; Shen, Dazhong1; Kang, Qi1; Chen, Lingxin2,4
Source PublicationANALYTICAL CHEMISTRY
ISSN0003-2700
2022-11-10
Pages10
DOI10.1021/acs.analchem.2c03208
Corresponding AuthorWang, Yunqing(yqwang@yic.ac.cn) ; Kang, Qi() ; Chen, Lingxin(lxchen@yic.ac.cn)
AbstractMicroneedles (MNs) are currently one of the most promising tools for skin interstitial fluid (ISF)-based biosensing, while it is still a challenge to expand the detectable biomarkers in ISF due to limited MNs types and detection techniques. Herein, highly sensitive internal-standard surface-enhanced Raman scattering microneedles (IS-SERS-MNs) were developed, which enabled the reliable detection of bacterial metabolites in ISF as new detectable biomarkers for infection diagnosis. The developed IS-SERS-MNs can not only directly detect pyocyanin (a representative bacterial metabolite) present in mouse dermal ISF but also indirectly detect pyocyanin in the hypodermis via its diffusion into the dermis, revealing a new possible pathway for the source of biomarkers in dermal ISF. Moreover, the SERS signal of pyocyanin was also clearly detected at real mouse wounds, indicating that the developed IS-SERS-MNs have great potential in minimally invasive and painless diagnosis of bacterial infection via a new ISF route. This work not only develops IS-SERS-MNs as a powerful tool for expanding the application of SERS-based MNs but also provides a new chance for ISF-related infection diagnosis.
Funding OrganizationNational Natural Science Foundation of China ; Science and Technology Development Plan of Shandong Province of China ; Youth Innovation Promotion Association CAS ; Instrument Developing Project of the Chinese Academy of Sciences
Indexed BySCI
Language英语
WOS KeywordNANOPARTICLES
WOS Research AreaChemistry
WOS IDWOS:000885666900001
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/32371
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Corresponding AuthorWang, Yunqing; Kang, Qi; Chen, Lingxin
Affiliation1.Shandong Normal Univ, Coll Chem, Key Lab Mol & NanoProbes, Chem Engn & Mat Sci,Minist Educ, Jinan 250014, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
4.Qingdao Univ Technol, Sch Environm & Municipal Engn, Qingdao 266033, Peoples R China
Recommended Citation
GB/T 7714
Mei, Rongchao,Wang, Yunqing,Shi, Shang,et al. Highly Sensitive and Reliable Internal-Standard Surface-Enhanced Raman Scattering Microneedles for Determination of Bacterial Metabolites as Infection Biomarkers in Skin Interstitial Fluid[J]. ANALYTICAL CHEMISTRY,2022:10.
APA Mei, Rongchao.,Wang, Yunqing.,Shi, Shang.,Zhao, Xizhen.,Zhang, Zhiyang.,...&Chen, Lingxin.(2022).Highly Sensitive and Reliable Internal-Standard Surface-Enhanced Raman Scattering Microneedles for Determination of Bacterial Metabolites as Infection Biomarkers in Skin Interstitial Fluid.ANALYTICAL CHEMISTRY,10.
MLA Mei, Rongchao,et al."Highly Sensitive and Reliable Internal-Standard Surface-Enhanced Raman Scattering Microneedles for Determination of Bacterial Metabolites as Infection Biomarkers in Skin Interstitial Fluid".ANALYTICAL CHEMISTRY (2022):10.
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