Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect
Mei, Rongchao1,2; Wang, Yunqing2; Zhao, Xizhen2; Shi, Shang2; Wang, Xiaoyan3; Zhou, Na2; Shen, Dazhong1; Kang, Qi1; Chen, Lingxin2
Source PublicationACS SENSORS
ISSN2379-3694
2023-01-13
Pages9
Keywordmicroneedles patch skin interstitial fluid surface-enhanced Raman scattering acute peritonitis
DOI10.1021/acssensors.2c02409
Corresponding AuthorWang, Yunqing(yqwang@yic.ac.cn) ; Kang, Qi(kangqi@sdnu.edu.cn) ; Chen, Lingxin(lxchen@yic.ac.cn)
AbstractSkin interstitial fluid (ISF)-based microneedle (MN) sensing has recently exhibited wide promise for the minimally invasive and painless diagnosis of diseases. However, it is still a great challenge to diagnose more disease types due to the limited in situ sensing techniques and insufficient ISF biomarker sources. Herein, ISF is employed to pioneer the tracking of acute peritonitis progression via surface-enhanced Raman scattering (SERS) tags labeled MNs patch technique. Densely deposited core-satellite gold nanoparticles and 3-mercaptophenylboronic acid as a Raman reporter enable the developed MNs patch with high sensitivity and selectivity in the determination of H2O2, an indicator of peritonitis development. Importantly, the MNs patch not only reliably tracks the different states of peritonitis but also evaluates the efficacy of drugs in the treatment of peritonitis, as evidenced by the altered SERS signal consistent with plasma pro-inflammatory factor (TNF-alpha) and peritoneum pathological manifestations. Interestingly, the major source of H2O2 in ISF of acute peritonitis investigated may not be through conventional blood capillary filtration pathway. This work provides a new route and technique for the early diagnosis of acute peritonitis and the evaluation of drug therapy effects. The developed MNs patch is promising to serve as a universal sensing tool to greatly enrich the variety and prospect of ISF-based disease diagnosis.
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Foundation of Shandong Province of China ; Taishan Scholars Program ; Instrument Developing Project of the Chinese Academy of Sciences ; Taishan Scholar Project Special Funding
Indexed BySCI
Language英语
WOS KeywordHYDROGEN-PEROXIDE ; CHEMILUMINESCENCE ; NANOPARTICLES ; BIOMARKERS ; GLUCOSE
WOS Research AreaChemistry ; Science & Technology - Other Topics
WOS IDWOS:000920315400001
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/32087
Collection中国科学院海岸带环境过程与生态修复重点实验室
中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Corresponding AuthorWang, Yunqing; Kang, Qi; Chen, Lingxin
Affiliation1.Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes, Minist Educ, Jinan 250014, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Mei, Rongchao,Wang, Yunqing,Zhao, Xizhen,et al. Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect[J]. ACS SENSORS,2023:9.
APA Mei, Rongchao.,Wang, Yunqing.,Zhao, Xizhen.,Shi, Shang.,Wang, Xiaoyan.,...&Chen, Lingxin.(2023).Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect.ACS SENSORS,9.
MLA Mei, Rongchao,et al."Skin Interstitial Fluid-Based SERS Tags Labeled Microneedles for Tracking of Peritonitis Progression and Treatment Effect".ACS SENSORS (2023):9.
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