Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples

doi:10.1016/j.talanta.2022.123726

	Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples
	Li, Xin 1; Zhao, Yuqing 1; Hao, Xiaowen 1; Wang, Xiaobin1 ; Luan, Feng 1; Tian, Chunyuan 1; Zhang, Zhiyang2 ; Yu, Shunyang2 ; Zhuang, Xuming 1
发表期刊	TALANTA
ISSN	0039-9140
	2022-12-01
卷号	250 页码:8
关键词	Ulinastatin Electrochemiluminescence Metal organic frameworks Self-luminescent Immunoassay
DOI	10.1016/j.talanta.2022.123726
通讯作者	Yu, Shunyang(syyu@yic.ac.cn) ; Zhuang, Xuming(xmzhuang@iccas.ac.cn)
英文摘要	In this work, we developed a novel electrochemiluminescence (ECL) biosensor for ulinastatin (UTI) detection based on self-luminescent metal-organic framework (L-MOF) nanomaterials. The L-MOFs could be simply pre -pared by one-pot methods using Eu3+ and 4,4 ',4 ''-s-triazine-1,3,5-triyltri-m-aminobenzoic acid (H(3)TATAB) as the metallic center and organic ligand, respectively. The Eu-TATAB exhibited high efficiency and stable ECL performance when using K2S2O8 as coreactant. For the established biosensor, Eu-TATAB was both used as the ECL chromophore and protein carrier due to its outstanding biocompatibility and large superficial area, which could load sufficient antibodies to link with antigen in the biosensor for subsequent detection. The established sandwich ECL biosensor showed a wide linear range of 0.1 ng mL(-1) - 10(5) ng mL(-1) and a low limit of detection of 9.7 pg mL(-1 )for UTI detection. In addition, the developed ECL biosensor could also be successfully applied to the real UTI sample determination in serum. The reported biosensor strategy could provide a guide for developing more other novel and promising high-performance ECL nanomaterials, and also be used as a potential method for ultrasensitive UTI detection in disease research.
资助机构	National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province ; Scientific Instru- ment Developing Project of the Chinese Academy of Sciences ; Key Science and Technology Program of Yantai
收录类别	SCI
语种	英语
关键词[WOS]	ELECTROGENERATED CHEMILUMINESCENCE ; MOF
研究领域[WOS]	Chemistry
WOS记录号	WOS:000829235400008
引用统计	被引频次：3[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31616
专题	中国科学院海岸带环境过程与生态修复重点实验室中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
通讯作者	Yu, Shunyang; Zhuang, Xuming
作者单位	1.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Li, Xin,Zhao, Yuqing,Hao, Xiaowen,et al. Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples[J]. TALANTA,2022,250:8.
APA	Li, Xin.,Zhao, Yuqing.,Hao, Xiaowen.,Wang, Xiaobin.,Luan, Feng.,...&Zhuang, Xuming.(2022).Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples.TALANTA,250,8.
MLA	Li, Xin,et al."Self-luminescent europium based metal organic frameworks nanorods as a novel electrochemiluminescence chromophore for sensitive ulinastatin detection in biological samples".TALANTA 250(2022):8.