Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release

doi:10.3390/md20050278

	Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release
	Mi, Yingqi 1,2; Zhang, Jingjing 1; Tan, Wenqiang1 ; Miao, Qin 1,2; Li, Qing1 ; Guo, Zhanyong1,2
发表期刊	MARINE DRUGS
	2022-05-01
卷号	20 期号:5 页码:18
关键词	chitosan nanoparticles cyclodextrin antioxidant activity antitumor activity drug release
DOI	10.3390/md20050278
英文摘要	In this study, chitosan nanoparticles (HF-CD NPs) were synthesized by an ionic gelation method using negatively charged carboxymethyl-beta-cyclodextrin and positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan bearing folic acid. The surface morphology of HF-CD NPs was spherical or oval, and they possessed relatively small particle size (192 +/- 8 nm) and positive zeta potential (+20 +/- 2 mV). Meanwhile, doxorubicin (Dox) was selected as model drug to investigate the prepared nanoparticles' potential to serve as a drug delivery carrier. The drug loading efficiency of drug-loaded nanoparticles (HF-Dox-CD NPs) was 31.25%. In vitro release profiles showed that Dox release of nanoparticles represented a pH-sensitive sustained and controlled release characteristic. At the same time, the antioxidant activity of nanoparticles was measured, and chitosan nanoparticles possessed good antioxidant activity and could inhibit the lipid peroxidation inside the cell and avoid material infection. Notably, CCK-8 assay testified that the nanoparticles were safe drug carriers and significantly enhanced the antitumor activity of Dox. The nanoparticles possessed good antioxidant activity, pH-sensitive sustained controlled release, enhanced antitumor activity, and could be expected to serve as a drug carrier in future with broad application prospects.
收录类别	SCI
语种	英语
关键词[WOS]	CHITOSAN NANOPARTICLES
研究领域[WOS]	Pharmacology & Pharmacy
WOS记录号	WOS:000801303600001
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31147
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Mi, Yingqi,Zhang, Jingjing,Tan, Wenqiang,et al. Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release[J]. MARINE DRUGS,2022,20(5):18.
APA	Mi, Yingqi,Zhang, Jingjing,Tan, Wenqiang,Miao, Qin,Li, Qing,&Guo, Zhanyong.(2022).Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release.MARINE DRUGS,20(5),18.
MLA	Mi, Yingqi,et al."Preparation of Doxorubicin-Loaded Carboxymethyl-beta-Cyclodextrin/Chitosan Nanoparticles with Antioxidant, Antitumor Activities and pH-Sensitive Release".MARINE DRUGS 20.5(2022):18.