Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model

doi:10.1007/s00253-022-12044-4

	Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model
	Yuan, Jingyi 1; Qin, Song1,2 ; Hu, Shanliang 3; Liu, Zhengyi1,2 ; Song, Yipeng 3; Li, Lili1,2
发表期刊	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN	0175-7598
	2022-07-02
卷号	106 期号:13-16 页码:5197-5209
关键词	Cefixime Prebiotic blend Gut microbiota Metabolome
研究领域	Biotechnology & Applied Microbiology
DOI	10.1007/s00253-022-12044-4
英文摘要	Recent studies have provided compelling evidence linking the composition of the gut microbiota, host diet, and host physiology. Prebiotics are substrates that are selectively utilized by host microorganisms, conferring health benefits. Prebiotics, such as prebiotic blends (PB), are commonly used worldwide in food processing. Here, microbiome-metabolomics was used to evaluate how PB affect gut microbes and metabolic functions in C57BL/6 J mice administered cefixime. We found favorable effects of PB on obesity outcomes. PB supplementation significantly increased the abundance of Bifidobacterium, Parabacteroides, Alloprevotella, Alistipes, and Dubosiella, and decreased that of Robinsoniella, Blautia, Lachnoclostridium, Coprobacillus, Hungatella, Erysipelatoclostridium, Helicobacter, Clostridium sensu stricto 1, Enterococcus, and Akkermansia compared to that in the cefixime administration (CEF) group. In particular, PB increased the abundance of Parabacteroides goldsteinii and suppressed that of Robinsoniella peoriensis and Akkermansia muciniphila. In addition, it regulated the levels of microbial metabolites such as unsaturated fatty acids and bile acids. Thus, PB can alleviate metabolic disorders induced by antibiotic intervention, indicating a potential dietary strategy for populations with antibiotic-associated diarrhea.
文章类型	Article
收录类别	SCI
语种	英语
研究领域[WOS]	Biotechnology & Applied Microbiology
WOS记录号	WOS:000819890400003
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/31012
专题	海岸带生物学与生物资源利用重点实验室海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
通讯作者	Li, Lili
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China 3.Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai, Peoples R China
推荐引用方式 GB/T 7714	Yuan, Jingyi,Qin, Song,Hu, Shanliang,et al. Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2022,106(13-16):5197-5209.
APA	Yuan, Jingyi,Qin, Song,Hu, Shanliang,Liu, Zhengyi,Song, Yipeng,&Li, Lili.(2022).Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,106(13-16),5197-5209.
MLA	Yuan, Jingyi,et al."Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 106.13-16(2022):5197-5209.