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Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization
Hu, Dan1; Zhang, Zhong1; Yuan, Li1; Li, Wenjun2; Guo, Yurong1; Zhang, Runguang1; Yang, Xingbin1; Peng, Hailong3
KeywordMicrogels Porous starch Phycocyanin Zebrafish Fluorescence imaging
Corresponding AuthorZhang, Zhong(zzhang@snnu.edu.cn) ; Peng, Hailong(peng_hailong@aliyun.com)
AbstractTraditional bioactive substances are often limited in practical application due to their poor stability and low solubility. Therefore, it is imperative to develop biocompatible high loading microgel carriers. In this study, a novel type of casein-porous starch microgel was prepared under ultra-high-pressure homogenization, by using porous starch with the honeycomb three-dimensional network porous structure. Molecular interaction force analysis and thermodynamic analysis showed that electrostatic interaction played a major role in the formation of microgels. Circular dichroism and Fourier transform infrared spectroscopy showed that homogenization and pH were the main factors, which affected the formation and structural stability of microgels. Compared with casein-glutinous rice starch microgels, the encapsulation efficiency and loading capacity of phycocyanin in casein-porous starch microgels were increased by 77.27% and 135.10%, respectively. Thus, casein-porous starch microgels could not only achieve a sustained release effect, but also effectively transport phycocyanin to the gastrointestinal tract of zebrafish, while achieving good fluorescence imaging in vivo. Ultimately, the prepared casein-porous starch microgels could enrich the nanocarriers material, and contribute to the research of safe and effective fluorescent imaging materials.
Funding OrganizationNational Natural Science Foundation of China ; Postdoctoral Program of Shaanxi Province ; Fundamental Research Fund of the Central University
Indexed BySCI
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS IDWOS:000729556500003
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorZhang, Zhong; Peng, Hailong
Affiliation1.Shaanxi Normal Univ, Shaanxi Engn Lab Food Green Proc & Safety Control, Engn Res Ctr High Value Utilizat Western Fruit Re, Xian Key Lab Characterist Fruit Storage & Preserv, Xian 710062, Shaanxi, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China
3.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China
Recommended Citation
GB/T 7714
Hu, Dan,Zhang, Zhong,Yuan, Li,et al. Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,193:127-136.
APA Hu, Dan.,Zhang, Zhong.,Yuan, Li.,Li, Wenjun.,Guo, Yurong.,...&Peng, Hailong.(2021).Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,193,127-136.
MLA Hu, Dan,et al."Load phycocyanin to achieve in vivo imaging of casein-porous starch microgels induced by ultra-high-pressure homogenization".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 193(2021):127-136.
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