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New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release
Mi, Yingqi1,2,3; Chen, Yuan4; Gu, Guodong5; Miao, Qin1,2,3; Tan, Wenqiang1,2; Li, Qing1,2; Guo, Zhanyong1,2,3
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
2021-12-01
Volume273Pages:11
KeywordChitosan Drug release Cell viability Antitumor activity
DOI10.1016/j.carbpol.2021.118623
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractIn this paper, adriamycin-incorporated chitosan nanoparticles were synthesized by ionic gelation using negatively charged carboxymethyl chitosan and positively charged 2-hydroxypropyltrimethyl ammonium chloride chitosan. The method was efficient to obtain nanoparticles with low polydispersity index and small hydrodynamic diameter. And high zeta potential value indicated that nanoparticles had good stability. The adriamycin release of nanoparticles represented a significant response to pH, with the fastest release in phosphate buffer solution at pH 6.8. Meanwhile, the antioxidant efficiency of nanoparticles was assayed, and nanoparticles represented significant enhancement in radicals scavenging activity. The assay of cell viability by CCK-8 test exhibited that nanoparticles led to statistically significant decrease in cell viability for four kinds of cancer cells (HEPG-2, A549, MCF-7, and BGC-823). It was indicated that the nanoparticles with enhanced biological activity, reduced cytotoxicity, and pH-sensitive release could be served as potential drug carrier in drug delivery system.
Funding OrganizationNational Key R&D Program of China ; Youth Innovation Promotion Association CAS ; Natural Science Foundation of Shangdong Province of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan
Indexed BySCI
Language英语
WOS KeywordCARBOXYMETHYL CHITOSAN ; CYTOTOXICITY ; DELIVERY ; CHLORIDE ; SULFATE
WOS Research AreaChemistry ; Polymer Science
WOS IDWOS:000704406600003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/30782
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Ludong Univ, Sch Chem & Mat Sci, Yantai 264025, Peoples R China
5.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
Recommended Citation
GB/T 7714
Mi, Yingqi,Chen, Yuan,Gu, Guodong,et al. New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release[J]. CARBOHYDRATE POLYMERS,2021,273:11.
APA Mi, Yingqi.,Chen, Yuan.,Gu, Guodong.,Miao, Qin.,Tan, Wenqiang.,...&Guo, Zhanyong.(2021).New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release.CARBOHYDRATE POLYMERS,273,11.
MLA Mi, Yingqi,et al."New synthetic adriamycin-incorporated chitosan nanoparticles with enhanced antioxidant, antitumor activities and pH-sensitive drug release".CARBOHYDRATE POLYMERS 273(2021):11.
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