| A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine | |
Wang, Chan1; Qi, Longbin2; Liang, Rongning2
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| 发表期刊 | ANALYTICAL METHODS
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| ISSN | 1759-9660 |
| 2021-02-07 | |
| 卷号 | 13期号:5页码:620-625 |
| DOI | 10.1039/d0ay02100h |
| 英文摘要 | Polymeric membrane potentiometric sensors based on molecularly imprinted polymers (MIPs) have been successfully designed for the detection of organic compounds both in ionic and neutral forms. However, most of these sensors are based on the non-covalent recognition interactions between the functional groups of the MIP in the polymeric sensing membrane and the target. These weak non-covalent interactions are unfavorable for the detection of hydrophilic organic compounds (e.g., dopamine). Herein novel MIP potentiometric sensor based covalent recognition for the determination of protonated dopamine is described. Uniform-sized boronate-based MIP beads are utilized as the recognition receptors. These receptors can covalently bind with dopamine with a cis-diol group to form a five-membered cyclic ester and thus provide a higher affinity because of the stronger nature of the covalent bonds. It has been found that the proposed electrode shows an excellent sensitivity towards dopamine with a detection limit of 2.1 mu M, which could satisfy the needs for in vivo analysis of dopamine in the brain of living animals. We believe that the covalent recognition MIP-based sensing strategy provides an appealing way to design MIP-based electrochemical and optical sensors with excellent sensing properties. |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21874151] ; Youth Innovation Promotion Association of CAS [2014190] ; Taishan Scholar Program of Shandong Province [tspd20181215] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 研究领域[WOS] | Chemistry ; Food Science & Technology ; Spectroscopy |
| WOS记录号 | WOS:000617018900004 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/30513 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Ctr Shandong Integrated Technol Transfer C, Yantai 264003, Shandong, Peoples R China; 2.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc & Ecol Remediat, YICCAS,Yantai Inst Coastal Zone Res YIC, Yantai 264003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Chan,Qi, Longbin,Liang, Rongning. A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine[J]. ANALYTICAL METHODS,2021,13(5):620-625. |
| APA | Wang, Chan,Qi, Longbin,&Liang, Rongning.(2021).A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine.ANALYTICAL METHODS,13(5),620-625. |
| MLA | Wang, Chan,et al."A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine".ANALYTICAL METHODS 13.5(2021):620-625. |
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| A molecularly imprin（460KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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