Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography
Song, Zhihua1; Li, Jinhua2; Lu, Wenhui3; Li, Bowei2; Liu, Jinqiu1; Wang, Yaqi1; Wang, Yumeng1; Zhang, Zhong4; Chen, Lingxin2
Source PublicationJOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
2021-10-25
Volume1656Pages:11
KeywordFosfomycin Zirconia coated silica materials Hydrophilic interaction liquid chromatography Chromatographic stationary phases Alkaloids and benzoic acids
DOI10.1016/j.chroma.2021.462529
Corresponding AuthorSong, Zhihua(zhihuasong08@yeah.net) ; Chen, Lingxin(lxchen@yic.ac.cn)
AbstractHydrophilic interaction liquid chromatography (HILIC) plays an important role in the analysis of compounds having high polarity. In this study, fosfomycin (F) was chosen as a new end-capping reagent, owing to the facile hydrolysis reaction of its epoxy group. Zirconia coated silica (ZrO2/SiO2) materials having good chemical and physical stability were prepared. D-glucose-6-phosphate (G) and D-fructose1,6bisphosphate (FDP) were modified onto the inner and outer surfaces of the ZrO2/SiO2 microbeads. The new end-capping reagent (F) was then bonded onto the surface of the modified material through Lewis acid-base interactions. The properties (morphology, Zr content, pore size, pore volume, and carbon content) of the stationary phases (SPs) were characterized. Finally, the resulting end-capped SPs were employed to separate alkaloids and benzoic acids. Multiple interactions, including HILIC, electrostatic repulsion, ion exchange and hydrogen bonding, contributed to the retention of the analytes on the SPs. On the F-FDP-ZrO2/SiO2 column, a theoretical plate number of 31,700 plates/m and an asymmetry factor of 1.63 were achieved for berberine, exhibiting good chromatographic performance. Furthermore, the FDPZrO2/SiO2 column showed good acid-base stability and good potential for the analysis of benzoic acid in Sprite and ginsenoside separations. Thus, the results indicated the significant potential of using F as an end-capping reagent. (C) 2021 Elsevier B.V. All rights reserved.
Funding OrganizationScience and Technology Innovation Development Plan of Yantai City of China ; National Demonstration Center for Experimental Pharmacy Education (Yantai University) ; Natural Science Foundation of Shandong Province ; Taishan Scholar Project Special Funding ; Shandong Key Laboratory of Coastal Environmental Processes, YICCAS ; Fundamental Research Fund of the Central University ; National Natural Science Foundation of China
Indexed BySCI
Language英语
WOS KeywordZIRCONIA STATIONARY PHASES ; PERFORMANCE ; ACID ; NANOPARTICLES ; SEPARATION ; SILICA
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS IDWOS:000696330300003
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/29765
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorSong, Zhihua; Chen, Lingxin
Affiliation1.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ,Sch Pharm, Yantai 264005, Peoples R China
2.Chinese Acad Sci, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
3.Qilu Univ Technol, Sch Light Ind & Engn, Shandong Acad Sci, Jinan 250353, Peoples R China
4.Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Shaanxi Engn Lab Food Green Proc & Safety Control, Xian, Shaanxi, Peoples R China
Recommended Citation
GB/T 7714
Song, Zhihua,Li, Jinhua,Lu, Wenhui,et al. Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography[J]. JOURNAL OF CHROMATOGRAPHY A,2021,1656:11.
APA Song, Zhihua.,Li, Jinhua.,Lu, Wenhui.,Li, Bowei.,Liu, Jinqiu.,...&Chen, Lingxin.(2021).Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography.JOURNAL OF CHROMATOGRAPHY A,1656,11.
MLA Song, Zhihua,et al."Synthesis and evaluation of fosfomycin group end-capped packing materials for hydrophilic interaction liquid chromatography".JOURNAL OF CHROMATOGRAPHY A 1656(2021):11.
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