| Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice | |
Li, Li-Li1,3 ; Wang, Yu-Ting1,2,3; Zhu, Li-Meng1,3; Liu, Zheng-Yi1,3; Ye, Chang-Qing2; Qin, Song1,3
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| 发表期刊 | SCIENTIFIC REPORTS
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| ISSN | 2045-2322 |
| 2020-01-22 | |
| 卷号 | 10期号:1页码:12 |
| DOI | 10.1038/s41598-020-58048-w |
| 通讯作者 | Ye, Chang-Qing(cqye@ntu.edu.cn) ; Qin, Song(sqin@yic.ac.cn) |
| 英文摘要 | Societal lifestyle changes, especially increased consumption of a high-fat diet lacking dietary fibers, lead to gut microbiota dysbiosis and enhance the incidence of adiposity and chronic inflammatory disease. We aimed to investigate the metabolic effects of inulin with different degrees of polymerization on high-fat diet-fed C57BL/6J mice and to evaluate whether different health outcomes are related to regulation of the gut microbiota. Short-chain and long-chain inulins exert beneficial effects through alleviating endotoxemia and inflammation. Antiinflammation was associated with a proportional increase in short-chain fatty acid-producing bacteria and an increase in the concentration of short-chain fatty acids. Inulin might decrease endotoxemia by increasing the proportion of Bifidobacterium and Lactobacillus, and their inhibition of endotoxin secretion may also contribute to antiinflammation. Interestingly, the beneficial health effects of long-chain inulin were more pronounced than those of short-chain inulin. Long-chain inulin was more dependent than short-chain inulin on species capable of processing complex polysaccharides, such as Bacteroides. A good understanding of inulin-gut microbiota-host interactions helps to provide a dietary strategy that could target and prevent high-fat diet-induced endotoxemia and inflammation through a prebiotic effect. |
| 资助机构 | Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Key R&D Program of China |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | LIPID-METABOLISM ; PREBIOTICS ; FRUCTANS ; RATS ; OLIGOSACCHARIDES ; MODULATION ; GLUCOSE ; OBESITY |
| 研究领域[WOS] | Science & Technology - Other Topics |
| WOS记录号 | WOS:000559822200002 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/28552 |
| 专题 | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Ye, Chang-Qing; Qin, Song |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Li-Li,Wang, Yu-Ting,Zhu, Li-Meng,et al. Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice[J]. SCIENTIFIC REPORTS,2020,10(1):12. |
| APA | Li, Li-Li,Wang, Yu-Ting,Zhu, Li-Meng,Liu, Zheng-Yi,Ye, Chang-Qing,&Qin, Song.(2020).Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice.SCIENTIFIC REPORTS,10(1),12. |
| MLA | Li, Li-Li,et al."Inulin with different degrees of polymerization protects against diet-induced endotoxemia and inflammation in association with gut microbiota regulation in mice".SCIENTIFIC REPORTS 10.1(2020):12. |
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| Inulin with differen（2913KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 请求全文 | |
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