Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models
He, Na1; Wang, Yude2; Huang, Yan2,3; Chen, Lingxin3; Wang, Xiaoyan2,3; Lv, Changjun2; Yue, Shouwei1
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
2020-11-21
Volume8Issue:43Pages:9899-9905
DOI10.1039/d0tb01969k
Corresponding AuthorChen, Lingxin(lxchen@yic.ac.cn) ; Lv, Changjun(lucky_lcj@sina.com) ; Yue, Shouwei(shouweiy@sdu.edu.cn)
AbstractAcute lung injury (ALI) is a diffuse inflammatory pulmonary damage caused by excessive ROS that break the coordination of normal physiological structures and functions. Hypochlorous acid (HOCl), one kind of ROS, is a hopeful biological marker for inflammation-related diseases. Therefore, the excessive generation of HOCl might be a significant reason for oxidative injury in ALI. Herein, we developed a fluorescent probe, namely BCy-HOCl, for quantitatively monitoring and visualizing HOCl in living cells and in vivo. The probe BCy-HOCl displayed a significant fluorescence signal enhancement towards HOCl with excellent selectivity and sensitivity. The variation of HOCl in the ALI cell model and ALI mouse model was evaluated with BCy-HOCl to clarify the relationship between ALI and HOCl. Our results verified that the HOCl levels conspicuously increased with the severity of the ALI. Thus, HOCl is likely to play a crucial part in the process of ALI, which will probably provide a new strategy for its treatment.
Funding OrganizationNational Nature Science Foundation of China ; Science and Technology Innovation Development Plan of Yantai of China ; Research Initiation Fund of Binzhou Medical University ; Taishan Scholar Project Special Funding
Indexed BySCI
Language英语
WOS KeywordRESPIRATORY-DISTRESS-SYNDROME ; IMAGING BASAL ; LIVE-CELL ; MITOCHONDRIA ; HCLO ; LYSOSOME
WOS Research AreaMaterials Science
WOS IDWOS:000588549200006
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/28336
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorChen, Lingxin; Lv, Changjun; Yue, Shouwei
Affiliation1.Shandong Univ, Qilu Hosp, Cheelo Coll Med, Rehabil Ctr, Jinan 250100, Peoples R China
2.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China
3.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
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He, Na,Wang, Yude,Huang, Yan,et al. Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(43):9899-9905.
APA He, Na.,Wang, Yude.,Huang, Yan.,Chen, Lingxin.,Wang, Xiaoyan.,...&Yue, Shouwei.(2020).Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models.JOURNAL OF MATERIALS CHEMISTRY B,8(43),9899-9905.
MLA He, Na,et al."Detection of hypochlorous acid fluctuation via a selective fluorescent probe in acute lung injury cells and mouse models".JOURNAL OF MATERIALS CHEMISTRY B 8.43(2020):9899-9905.
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