| Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity | |
Mi, Yingqi1,2,3; Tan, Wenqiang1,2 ; Zhang, Jingjing1,2; Guo, Zhanyong1,2,3
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| Source Publication | POLYMERS
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| 2020-11-01 | |
| Volume | 12Issue:11Pages:16 |
| Keyword | antioxidant activity hydroxypropyltrimethyl ammonium chloride chitosan organic acid salt ion exchange |
| DOI | 10.3390/polym12112460 |
| Corresponding Author | Guo, Zhanyong(zhanyongguo@hotmail.com) |
| Abstract | A novel and green method for the preparation of chitosan derivatives bearing organic acids was reported in this paper. In order to improve the antioxidant activity of chitosan, eight different hydroxypropyltrimethyl ammonium chitosan derivatives were successfully designed and synthesized via introducing of organic acids onto chitosan by mild and non-toxic ion exchange. The data of Fourier Transform Infrared (FTIR), C-13 Nuclear Magnetic Resonance (NMR), H-1 NMR, and elemental analysis for chitosan derivatives indicated the successful conjugation of organic acid salt with hydroxypropyltrimethyl ammonium chloride chitosan (HACC). Meanwhile, the antioxidant activity of the chitosan derivatives was evaluated in vitro. The results indicated that the chitosan derivatives possessed dramatic enhancements in DPPH-radical scavenging activity, superoxide-radical scavenging activity, hydroxyl radical scavenging ability, and reducing power. Furthermore, the cytotoxicity of the synthesized compounds was investigated in vitro on L929 cells and showed low cytotoxicity. Thus, the enhanced antioxidant property of all novel chitosan products might be a great advantage, while applied in a wide range of applications in the form of antioxidant in biomedical, food, and cosmetic industry. |
| Funding Organization | National Key R&D Program of China ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | CHLORIDE CHITOSAN ; IN-VITRO ; DERIVATIVES |
| WOS Research Area | Polymer Science |
| WOS ID | WOS:000593845900001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/28303 |
| Collection | 海岸带生物学与生物资源利用重点实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 |
| Corresponding Author | Guo, Zhanyong |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,et al. Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity[J]. POLYMERS,2020,12(11):16. |
| APA | Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,&Guo, Zhanyong.(2020).Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity.POLYMERS,12(11),16. |
| MLA | Mi, Yingqi,et al."Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity".POLYMERS 12.11(2020):16. |
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| Modification of Hydr（4875KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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