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Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity
Mi, Yingqi1,2,3; Tan, Wenqiang1,2; Zhang, Jingjing1,2; Guo, Zhanyong1,2,3
Source PublicationPOLYMERS
2020-11-01
Volume12Issue:11Pages:16
Keywordantioxidant activity hydroxypropyltrimethyl ammonium chloride chitosan organic acid salt ion exchange
DOI10.3390/polym12112460
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
AbstractA novel and green method for the preparation of chitosan derivatives bearing organic acids was reported in this paper. In order to improve the antioxidant activity of chitosan, eight different hydroxypropyltrimethyl ammonium chitosan derivatives were successfully designed and synthesized via introducing of organic acids onto chitosan by mild and non-toxic ion exchange. The data of Fourier Transform Infrared (FTIR), C-13 Nuclear Magnetic Resonance (NMR), H-1 NMR, and elemental analysis for chitosan derivatives indicated the successful conjugation of organic acid salt with hydroxypropyltrimethyl ammonium chloride chitosan (HACC). Meanwhile, the antioxidant activity of the chitosan derivatives was evaluated in vitro. The results indicated that the chitosan derivatives possessed dramatic enhancements in DPPH-radical scavenging activity, superoxide-radical scavenging activity, hydroxyl radical scavenging ability, and reducing power. Furthermore, the cytotoxicity of the synthesized compounds was investigated in vitro on L929 cells and showed low cytotoxicity. Thus, the enhanced antioxidant property of all novel chitosan products might be a great advantage, while applied in a wide range of applications in the form of antioxidant in biomedical, food, and cosmetic industry.
Funding OrganizationNational Key R&D Program of China ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan
Indexed BySCI
Language英语
WOS KeywordCHLORIDE CHITOSAN ; IN-VITRO ; DERIVATIVES
WOS Research AreaPolymer Science
WOS IDWOS:000593845900001
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/28303
Collection海岸带生物学与生物资源利用重点实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,et al. Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity[J]. POLYMERS,2020,12(11):16.
APA Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,&Guo, Zhanyong.(2020).Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity.POLYMERS,12(11),16.
MLA Mi, Yingqi,et al."Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity".POLYMERS 12.11(2020):16.
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