对不同分子质量段的鱼皮胶原多肽口服生物利用度进行研究。在分子质量越小越容易被吸收的基础上,利用低于6ku的3个分子质量段（小于1ku,1-3ku,3-6ku）的多肽对大鼠进行实验,通过测定其粪便、尿液、血液中的羟脯氨酸含量,选择一种生物利用度较高的胶原多肽。结果表明,分子质量段为1-3ku的鳕鱼皮胶原多肽具有较高的口服生物利用度。得到一种高口服生物利用度的胶原多肽,为保健品的研发奠定了基础。

This study researched different molecular weight peptides on oral bio-availability. On the basis of smaller molecular weight with easier absorbed,three molecular weight peptides（〈 1 ku,1- 3 ku,3- 6 ku） were experimented on rat,then chose a collagen peptides with high oral bio-availability by determining the hydroxyproline content of feces,urine,and blood. The result showed that 1- 3ku cod skin collagen peptides exhibits higher oral bio-availability. This research would provide a base for health care production.