Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor | |
Wang, Yue1,2; Chen, Lingxin1,3![]() | |
发表期刊 | JOURNAL OF MEDICINAL CHEMISTRY
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ISSN | 0022-2623 |
2021-03-25 | |
卷号 | 64期号:6页码:2967-2970 |
DOI | 10.1021/acs.jmedchem.1c00433 |
通讯作者 | Chen, Lingxin(lxchen@yic.ac.cn) |
英文摘要 | Both nitroreductase and the folate receptor are highly expressed in hypoxic tumors. The folate receptor is a potential target for tumors, and nitroreductase can selectively turn on the fluorescence of probes by reducing the nitro group to an amino group. Karan et al. (Karana, S., Cho, M., Lee, H., Lee, H., Park, H., Sundararajan, M., Sessler, J., and Hong, K. Near-infrared fluorescent probe activated by nitroreductase for in vitro and in vivo hypoxic tumor detection. J. Med. Chem. 2021) developed a near-infrared fluorescent probe for hypoxia tumor imaging analysis in vitro and in vivo using folate as the targeting site. This promising strategy may promote advances in precision diagnosis and treatment models of malignant tumors. This Viewpoint looks ahead to new possibilities rendered by their studies. |
资助机构 | National Natural Science Foundation of China ; Taishan Scholar Project Special Funding |
收录类别 | SCI |
语种 | 英语 |
研究领域[WOS] | Pharmacology & Pharmacy |
WOS记录号 | WOS:000635440600007 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/27236 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
通讯作者 | Chen, Lingxin |
作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yue,Chen, Lingxin. Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor[J]. JOURNAL OF MEDICINAL CHEMISTRY,2021,64(6):2967-2970. |
APA | Wang, Yue,&Chen, Lingxin.(2021).Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor.JOURNAL OF MEDICINAL CHEMISTRY,64(6),2967-2970. |
MLA | Wang, Yue,et al."Smart Fluorescent Probe Strategy for Precision Targeting Hypoxic Tumor".JOURNAL OF MEDICINAL CHEMISTRY 64.6(2021):2967-2970. |
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Smart Fluorescent Pr(1079KB) | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 |
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