Rational construction of a triple emission molecular imprinting sensor for accurate naked-eye detection of folic acid
Yang, Qian; Li, Chuyao; Li, Jinhua; Wang, Xiaoyan; Arabi, Maryam; Peng, Hailong; Xiong, Hua; Chen, Lingxin
Source PublicationNANOSCALE
2020-03-21
Volume12Issue:11Pages:6529-6536
KeywordFLUORESCENCE SENSORS QUANTUM DOTS CARBON DOTS POLYMERS RECOGNITION
MOST Discipline CatalogueChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
DOI10.1039/d0nr00765j
Contribution Rank[Yang, Qian; Li, Chuyao; Peng, Hailong; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China; [Yang, Qian; Li, Chuyao; Li, Jinhua; Wang, Xiaoyan; Arabi, Maryam; Chen, Lingxin] Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Wang, Xiaoyan; Chen, Lingxin] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China; [Chen, Lingxin] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
Department海岸带环境工程技术研究与发展中心
AbstractMultiple emissions of blue, green and red from a molecular imprinting sensor rationally constructed, were used for the fluorescence colorimetric visualization of a fluorescent analyte of folic acid, using a flexible post-imprinting mixing strategy. That is, two kinds of folic acid-templated molecularly imprinted polymers (MIPs) were firstly synthesized by encapsulating green and red fluorescent quantum dots (g-QDs and r-QDs) individually on SiO2 cores, and they were then mixed at an appropriate ratio, resulting in a triple emission MIPs sensor. Upon folic acid recognition, the inherent blue fluorescence of folic acid was intensified, and the green and red fluorescence of the sensor QDs were gradually quenched. The quenching rate difference between g-QDs and r-QDs was greatly enhanced and used to obtain a wider-range and profuse fluorescence color evolution, by investigating the influences of the QDs modifier, eluent and imprinting layer thickness in detail. Under optimal conditions, the ratiometric intensity change of the three color emissions varied in a logistic function within 0.01-50 ppm of folic acid, and the corresponding fluorescence colors shifted from yellow to orange to red to purple and finally to blue. This excellent visualization capability of the MIPs sensor contributed to the accurate naked-eye detection of folic acid concentration using a portable ultraviolet lamp. Moreover, the MIPs sensor succeeded in determining folic acid in complicated food and serum samples, providing comparable results with the PRC standard method and satisfactory recoveries of 99.5-108.0%. The merits, including construction simplicity, high sensitivity and selectivity, and result visualization, enable such a multiple emission MIPs sensing strategy to be potentially applicable for visual identification and determination of various analytes in more fields.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordFLUORESCENCE SENSORS ; QUANTUM DOTS ; CARBON DOTS ; POLYMERS ; RECOGNITION
WOS IDWOS:000522124800030
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China [21667018, 21876199, 31860470, 21804010, 21976209, 31660482] ; Science and Technology Development Plan of Yantai City of China ; Chinese Academy of Sciences President's International Fellowship Initiative [2019PC0050] ; Taishan Scholar Project Special Fund [ts20190962]
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/25066
Collection中科院海岸带环境过程与生态修复重点实验室_海岸带环境工程技术研究与发展中心
Affiliation1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China;
2.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
3.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China;
4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
Recommended Citation
GB/T 7714
Yang, Qian,Li, Chuyao,Li, Jinhua,et al. Rational construction of a triple emission molecular imprinting sensor for accurate naked-eye detection of folic acid[J]. NANOSCALE,2020,12(11):6529-6536.
APA Yang, Qian.,Li, Chuyao.,Li, Jinhua.,Wang, Xiaoyan.,Arabi, Maryam.,...&Chen, Lingxin.(2020).Rational construction of a triple emission molecular imprinting sensor for accurate naked-eye detection of folic acid.NANOSCALE,12(11),6529-6536.
MLA Yang, Qian,et al."Rational construction of a triple emission molecular imprinting sensor for accurate naked-eye detection of folic acid".NANOSCALE 12.11(2020):6529-6536.
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