Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications
Qin, Yukun; Li, Pengcheng; Guo, Zhanyong
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
2020-05-15
Volume236Pages:116002
KeywordCANDIDA-ALBICANS BIOFILMS N-PHTHALOYL-CHITOSAN OF-THE-ART ANTIBACTERIAL ACTIVITY ANTIMICROBIAL ACTIVITY QUATERNIZED CHITOSAN DRUG-DELIVERY EDIBLE FILMS IN-VITRO DIETHYLAMINOETHYL CHITOSAN
MOST Discipline CatalogueChemistry, Applied ; Chemistry, Organic ; Polymer Science
DOI10.1016/j.carbpol.2020.116002
Contribution Rank[Qin, Yukun; Li, Pengcheng] Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China; [Qin, Yukun; Li, Pengcheng] Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China; [Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
Corresponding AuthorLi, Pengcheng(pcli@qdio.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
Department海岸带生物资源高效利用研究与发展中心
AbstractThe increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.
SubtypeReview
Indexed BySCI
Language英语
WOS KeywordCANDIDA-ALBICANS BIOFILMS ; N-PHTHALOYL-CHITOSAN ; OF-THE-ART ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; QUATERNIZED CHITOSAN ; DRUG-DELIVERY ; EDIBLE FILMS ; IN-VITRO ; DIETHYLAMINOETHYL CHITOSAN
WOS Research AreaChemistry ; Polymer Science
Funding ProjectNational Key R&D Program of China[2018YFC0311305] ; National Key R&D Program of China[2019YFD0900705] ; Key Research and Development Program of Shandong Province[2018GHY115017] ; Qingdao Applied Basic Research Project[19-6-2-34-cg] ; Science and technology program of Nantong[MS120170234]
WOS IDWOS:000519306900012
Funding OrganizationNational Key R&D Program of China [2018YFC0311305, 2019YFD0900705] ; Key Research and Development Program of Shandong Province [2018GHY115017] ; Qingdao Applied Basic Research Project [19-6-2-34-cg] ; Science and technology program of Nantong [MS120170234]
Citation statistics
Cited Times:30[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/25034
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Affiliation1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China;
2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China;
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
Recommended Citation
GB/T 7714
Qin, Yukun,Li, Pengcheng,Guo, Zhanyong. Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications[J]. CARBOHYDRATE POLYMERS,2020,236:116002.
APA Qin, Yukun,Li, Pengcheng,&Guo, Zhanyong.(2020).Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications.CARBOHYDRATE POLYMERS,236,116002.
MLA Qin, Yukun,et al."Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications".CARBOHYDRATE POLYMERS 236(2020):116002.
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