Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

doi:10.1016/j.carbpol.2020.116002

YIC-IR > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications
	Qin, Yukun ; Li, Pengcheng ; Guo, Zhanyong
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
	2020-05-15
卷号	236 页码:116002
关键词	CANDIDA-ALBICANS BIOFILMS N-PHTHALOYL-CHITOSAN OF-THE-ART ANTIBACTERIAL ACTIVITY ANTIMICROBIAL ACTIVITY QUATERNIZED CHITOSAN DRUG-DELIVERY EDIBLE FILMS IN-VITRO DIETHYLAMINOETHYL CHITOSAN
研究领域	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
DOI	10.1016/j.carbpol.2020.116002
产权排序	[Qin, Yukun; Li, Pengcheng] Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China; [Qin, Yukun; Li, Pengcheng] Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China; [Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
通讯作者	Li, Pengcheng(pcli@qdio.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
作者部门	海岸带生物资源高效利用研究与发展中心
英文摘要	The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.
文章类型	Review
资助机构	National Key R&D Program of China [2018YFC0311305, 2019YFD0900705] ; Key Research and Development Program of Shandong Province [2018GHY115017] ; Qingdao Applied Basic Research Project [19-6-2-34-cg] ; Science and technology program of Nantong [MS120170234]
收录类别	SCI
语种	英语
关键词[WOS]	CANDIDA-ALBICANS BIOFILMS ; N-PHTHALOYL-CHITOSAN ; OF-THE-ART ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; QUATERNIZED CHITOSAN ; DRUG-DELIVERY ; EDIBLE FILMS ; IN-VITRO ; DIETHYLAMINOETHYL CHITOSAN
研究领域[WOS]	Chemistry ; Polymer Science
WOS记录号	WOS:000519306900012
引用统计	被引频次：99[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/25034
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China; 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Qin, Yukun,Li, Pengcheng,Guo, Zhanyong. Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications[J]. CARBOHYDRATE POLYMERS,2020,236:116002.
APA	Qin, Yukun,Li, Pengcheng,&Guo, Zhanyong.(2020).Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications.CARBOHYDRATE POLYMERS,236,116002.
MLA	Qin, Yukun,et al."Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications".CARBOHYDRATE POLYMERS 236(2020):116002.

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