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	Dual-Analyte Chronopotentiometric Aptasensing Platform Based on a G-Quadruplex/Hemin DNAzyme and Logic Gate Operations
	Liu, SW; Ding, JW; Qin, W
发表期刊	ANALYTICAL CHEMISTRY
ISSN	0003-2700
	2019-02-19
卷号	91期号:4页码:3170-3176
关键词	ION-SELECTIVE ELECTRODES SOLID-CONTACT LABEL-FREE COLORIMETRIC DETECTION MEMBRANE ELECTRODES APTAMER MOLECULES CYSTEINE SYSTEMS SENSORS
研究领域	Chemistry, Analytical
DOI	10.1021/acs.analchem.8b05971
产权排序	[Liu, Shuwen; Ding, Jiawang; Qin, Wei] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China; [Liu, Shuwen; Ding, Jiawang; Qin, Wei] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China; [Ding, Jiawang; Qin, Wei] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266200, Peoples R China; [Liu, Shuwen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
作者部门	海岸带环境过程实验室
英文摘要	Conventional potentiometric ion sensors that rely on a specific ion carrier in a polymeric membrane can hardly achieve multianalyte detection. Inspired by the remarkable ability of built-in logic gate sensors for multianalyte detection, herein we report a potentiometric aptasensing platform based on a G-quadruplex/hemin DNAzyme and logic gate operations for determination of two analytes using a single membrane electrode. A bifunctional probe with two aptamer units and a signal reporter oligonucleotide with a DNAzyme sequence are assembled on the magnetic beads to form a DNA hybrid structure. The "OR" and "INHIBIT" logic functions can be performed by using the two aptamers and their targets as inputs, and using the chronopotentiometric response based on the G-quadruplex/hemin DNAzyme-H2O2-mediated oxidation of 3,3',5,5'-tetramethylbenzidine as output. Kanamycin and oxytetracycline, as commonly used antibiotics, have been employed as the models and successfully measured.
文章类型	Article
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21575158, 21475148, 41876108] ; National Key Research and Development Program of China [2016YFC1400700] ; Instrument Developing Project of the Chinese Academy of Sciences [Y728021021] ; Taishan Scholar Program of Shandong Province [TS20081159]
收录类别	SCI
语种	英语
关键词[WOS]	ION-SELECTIVE ELECTRODES ; SOLID-CONTACT ; LABEL-FREE ; COLORIMETRIC DETECTION ; MEMBRANE ELECTRODES ; APTAMER ; MOLECULES ; CYSTEINE ; SYSTEMS ; SENSORS
研究领域[WOS]	Chemistry, Analytical
WOS记录号	WOS:000459642400083
引用统计	被引频次：32[WOS]   [WOS记录]     [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24998
专题	中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中国科学院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Shandong, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Environm Proc, Yantai 264003, Shandong, Peoples R China; 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266200, Peoples R China; 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liu, SW,Ding, JW,Qin, W. Dual-Analyte Chronopotentiometric Aptasensing Platform Based on a G-Quadruplex/Hemin DNAzyme and Logic Gate Operations[J]. ANALYTICAL CHEMISTRY,2019,91(4):3170-3176.
APA	Liu, SW,Ding, JW,&Qin, W.(2019).Dual-Analyte Chronopotentiometric Aptasensing Platform Based on a G-Quadruplex/Hemin DNAzyme and Logic Gate Operations.ANALYTICAL CHEMISTRY,91(4),3170-3176.
MLA	Liu, SW,et al."Dual-Analyte Chronopotentiometric Aptasensing Platform Based on a G-Quadruplex/Hemin DNAzyme and Logic Gate Operations".ANALYTICAL CHEMISTRY 91.4(2019):3170-3176.

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