| Evaluation of quaternary ammonium chitosan derivatives differing in the length of alkyl side-chain: Synthesis and antifungal activity | |
Wei, LJ; Mi, YQ; Zhang, JJ; Li, Q ; Dong, F; Guo, ZY
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| 发表期刊 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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| ISSN | 0141-8130 |
| 2019-05-15 | |
| 卷号 | 129页码:1127-1132 |
| 关键词 | Chitosan Quaternary Antifungal |
| 研究领域 | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| DOI | 10.1016/j.ijbiomac.2018.09.099 |
| 产权排序 | [Wei, Lijie; Mi, Yingqi; Zhang, Jingjing; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Wei, Lijie; Mi, Yingqi; Zhang, Jingjing; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 通讯作者 | Dong, Fang(fdong@yic.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com) |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | Chemical modification is one of the prominent methods used to improve the water solubility and bioactivity of chitosan. In this paper, a series of quaternary ammonium chitosan derivatives based on 6-O-chloroacetylated chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FT-IR, H-1 NMR spectroscopy, and elemental analysis. Furthermore, the antifungal activity against Botrytis cinerea, Gibberella zeae, and Physalospora piricola Nose was estimated using in vitro hypha measurements. Most of the quaternary ammonium chitosan derivatives showed an inhibitory index of >90% at 1.0 mg/mL and exhibited enhanced antifungal activity when compared to chitosan. On one hand, the higher density of positive charge contributed to the antifungal action. In addition, the inhibitory activity decreased roughly in the order of TriM [(CH3)(3)] > TriE (CH2CH3)(3)] > TriP [(CH2CH2CH3)(3)] > TriB [(CH2CH2CH2CH3)(3)]; NNTE (CH3)(2)(CH2CH3)] > NNTB [(CH3)(2)(CH2CH2CH2CH3)] > NNTK RCH3)(2)((CH2)(9)CH3)] at 1.0 mg/mL. The antifungal properties of all the quaternary ammonium chitosan derivatives against the targeted fungi decreased upon increasing the alkyl chain length. (C) 2018 Published by Elsevier B.V. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | N-SUBSTITUTED CHITOSAN ; OLIGOCHITOSAN ; DYE |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| WOS记录号 | WOS:000466621200119 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24940 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, LJ,Mi, YQ,Zhang, JJ,et al. Evaluation of quaternary ammonium chitosan derivatives differing in the length of alkyl side-chain: Synthesis and antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2019,129:1127-1132. |
| APA | Wei, LJ,Mi, YQ,Zhang, JJ,Li, Q,Dong, F,&Guo, ZY.(2019).Evaluation of quaternary ammonium chitosan derivatives differing in the length of alkyl side-chain: Synthesis and antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,129,1127-1132. |
| MLA | Wei, LJ,et al."Evaluation of quaternary ammonium chitosan derivatives differing in the length of alkyl side-chain: Synthesis and antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 129(2019):1127-1132. |
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