Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications
Zhang, JJ; Tan, WQ; Wei, LJ; Chen, Y; Mi, YQ; Sun, XQ; Li, Q; Dong, F; Guo, ZY
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
2019-07-01
Volume215Pages:108-118
KeywordAntifungal activity Antioxidant activity Chitosan derivatives Structural characteristics Urea groups
MOST Discipline CatalogueChemistry, Applied ; Chemistry, Organic ; Polymer Science
DOI10.1016/j.carbpol.2019.03.067
Contribution Rank[Zhang, Jingjing; Tan, Wenqiang; Wei, Lijie; Chen, Yuan; Mi, Yingqi; Sun, Xueqi; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Zhang, Jingjing; Wei, Lijie; Chen, Yuan; Mi, Yingqi; Sun, Xueqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
Department海岸带生物学与生物资源保护实验室
AbstractIn the current study, five novel urea-functionalized chitosan derivatives were synthesized via condensation reactions of chloroacetyl chitosan (CTCS) with urea groups bearing nitrogen-containing heterocycles. In order to identify the structure characteristics of chitosan derivatives, FT-IR, H-1 NMR spectroscopy, and elemental analysis were carried out. The antifungal activity of the derivatives against four species of phytopathogen (Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, Fusarium oxysporum f. sp. cucumebrium Owen, and Botrytis cinerea) was evaluated. Furthermore, the antioxidant activity of chitosan derivatives was tested by hydroxyl-radical scavenging and superoxide-radical scavenging assays. The results indicated that chitosan derivatives bearing urea groups displayed superior bioactivity compared with chitosan. Besides, L929 cells were adopted for cytotoxicity test of chitosan and synthesized samples by CCK-8 assay and all samples showed decreased cytotoxicity. These results suggested that the novel urea-functionalized chitosan derivatives could be an ideal biomaterial for antifungal and antioxidant applications.
SubtypeArticle
Funding OrganizationNational Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Science and Technology Service Network Initiative of Chinese academy of sciences [KFJ-STS-ZDTP-023] ; Public Science and Technology Research Funds Projects of Ocean [2015418022-3] ; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011]
Indexed BySCI
Language英语
WOS KeywordANTIBACTERIAL ; NANOPARTICLES ; EFFICIENCY ; HYDROGELS ; FILM
WOS Research AreaChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000464112700013
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24915
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, JJ,Tan, WQ,Wei, LJ,et al. Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications[J]. CARBOHYDRATE POLYMERS,2019,215:108-118.
APA Zhang, JJ.,Tan, WQ.,Wei, LJ.,Chen, Y.,Mi, YQ.,...&Guo, ZY.(2019).Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications.CARBOHYDRATE POLYMERS,215,108-118.
MLA Zhang, JJ,et al."Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications".CARBOHYDRATE POLYMERS 215(2019):108-118.
Files in This Item: Download All
File Name/Size DocType Version Access License
Synthesis of urea-fu(2908KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Zhang, JJ]'s Articles
[Tan, WQ]'s Articles
[Wei, LJ]'s Articles
Baidu academic
Similar articles in Baidu academic
[Zhang, JJ]'s Articles
[Tan, WQ]'s Articles
[Wei, LJ]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Zhang, JJ]'s Articles
[Tan, WQ]'s Articles
[Wei, LJ]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications.pdf
Format: Adobe PDF
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.