Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications

doi:10.1016/j.carbpol.2019.03.067

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	Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications
	Zhang, JJ ; Tan, WQ; Wei, LJ ; Chen, Y ; Mi, YQ ; Sun, XQ ; Li, Q; Dong, F; Guo, ZY
发表期刊	CARBOHYDRATE POLYMERS
ISSN	0144-8617
	2019-07-01
卷号	215 页码:108-118
关键词	Antifungal activity Antioxidant activity Chitosan derivatives Structural characteristics Urea groups
研究领域	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
DOI	10.1016/j.carbpol.2019.03.067
产权排序	[Zhang, Jingjing; Tan, Wenqiang; Wei, Lijie; Chen, Yuan; Mi, Yingqi; Sun, Xueqi; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Zhang, Jingjing; Wei, Lijie; Chen, Yuan; Mi, Yingqi; Sun, Xueqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
作者部门	海岸带生物学与生物资源保护实验室
英文摘要	In the current study, five novel urea-functionalized chitosan derivatives were synthesized via condensation reactions of chloroacetyl chitosan (CTCS) with urea groups bearing nitrogen-containing heterocycles. In order to identify the structure characteristics of chitosan derivatives, FT-IR, H-1 NMR spectroscopy, and elemental analysis were carried out. The antifungal activity of the derivatives against four species of phytopathogen (Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, Fusarium oxysporum f. sp. cucumebrium Owen, and Botrytis cinerea) was evaluated. Furthermore, the antioxidant activity of chitosan derivatives was tested by hydroxyl-radical scavenging and superoxide-radical scavenging assays. The results indicated that chitosan derivatives bearing urea groups displayed superior bioactivity compared with chitosan. Besides, L929 cells were adopted for cytotoxicity test of chitosan and synthesized samples by CCK-8 assay and all samples showed decreased cytotoxicity. These results suggested that the novel urea-functionalized chitosan derivatives could be an ideal biomaterial for antifungal and antioxidant applications.
文章类型	Article
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Science and Technology Service Network Initiative of Chinese academy of sciences [KFJ-STS-ZDTP-023] ; Public Science and Technology Research Funds Projects of Ocean [2015418022-3] ; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011]
收录类别	SCI
语种	英语
关键词[WOS]	ANTIBACTERIAL ; NANOPARTICLES ; EFFICIENCY ; HYDROGELS ; FILM
研究领域[WOS]	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS记录号	WOS:000464112700013
引用统计	被引频次：34[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.yic.ac.cn/handle/133337/24915
专题	海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, JJ,Tan, WQ,Wei, LJ,et al. Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications[J]. CARBOHYDRATE POLYMERS,2019,215:108-118.
APA	Zhang, JJ.,Tan, WQ.,Wei, LJ.,Chen, Y.,Mi, YQ.,...&Guo, ZY.(2019).Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications.CARBOHYDRATE POLYMERS,215,108-118.
MLA	Zhang, JJ,et al."Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications".CARBOHYDRATE POLYMERS 215(2019):108-118.

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