Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities
Zhang, JJ; Sun, XQ; Chen, Y; Mi, YQ; Tan, WQ; Miao, Q; Li, Q; Dong, F; Guo, ZY
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
2020-04-15
Volume234Pages:115903
KeywordAntifungal activity Antioxidant activity Chitosan oligosaccharide derivatives Cytotoxicity Urea groups
MOST Discipline CatalogueChemistry, Applied ; Chemistry, Organic ; Polymer Science
DOI10.1016/j.carbpol.2020.115903
Contribution Rank[Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Miao, Qin; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Tan, Wenqiang; Miao, Qin; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; [Zhang, Jingjing; Sun, Xueqi; Chen, Yuan; Mi, Yingqi; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Department海岸带生物资源高效利用研究与发展中心
AbstractIn this study, 2-urea-chitosan oligosaccharide derivatives (2-urea-COS derivatives) and 2,6-diurea-chitosan oligosaccharide derivatives (2,6-diurea-COS derivatives) were successfully designed and synthesized via intermediate 2-methoxyformylated chitosan oligosaccharide. All samples were characterized and compared based on FT-IR, H-1 NMR spectroscopy, and elemental analysis. The antifungal effects of COS derivatives were tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Botrytis cinereal. Their antioxidant properties, including superoxide radicals' scavenging activity, hydroxyl radicals' scavenging activity, and DPPH radicals' scavenging activity were also explored within different concentrations. COS derivatives bearing urea groups showed improved bioactivity compared with pristine COS and 2,6-diurea-COS derivatives had a higher biological activity than 2-urea-COS derivatives in tested concentrations. Additionally, L929 cells were used to carry out cytotoxicity test of COS and COS derivatives by CCK-8 assay. The results indicated that some of samples showed low cytotoxicity. These findings offered a suggestion that COS derivatives bearing urea groups are promising biological materials.
SubtypeArticle
Indexed BySCI
Language英语
WOS KeywordCHITOSAN DERIVATIVES ; IN-VITRO
WOS Research AreaChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000513917300027
Funding OrganizationNational Key R&D Program of China [2019YFD0900705] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2019BD064, ZR2017BD015] ; Youth Innovation Promotion Association CAS [2020219] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province Science and Technology Development Plan [2019GHY112010]
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24737
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
Affiliation1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China;
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, JJ,Sun, XQ,Chen, Y,et al. Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities[J]. CARBOHYDRATE POLYMERS,2020,234:115903.
APA Zhang, JJ.,Sun, XQ.,Chen, Y.,Mi, YQ.,Tan, WQ.,...&Guo, ZY.(2020).Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities.CARBOHYDRATE POLYMERS,234,115903.
MLA Zhang, JJ,et al."Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities".CARBOHYDRATE POLYMERS 234(2020):115903.
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