| Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity | |
Zhang, Jingjing; Tan, Wenqiang ; Mi, Yingqi; Luan, Fang; Wei, Lijie; Li, Qing; Dong, Fang; Guo, Zhanyong
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| 发表期刊 | STARCH-STARKE
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| ISSN | 0038-9056 |
| 2019-01 | |
| 卷号 | 71期号:1-2页码:1800058- |
| 关键词 | antifungal activity inulin derivatives structure characteristics synthesis urea groups |
| 研究领域 | Food Science & Technology |
| DOI | 10.1002/star.201800058 |
| 产权排序 | [Zhang, Jingjing; Tan, Wenqiang; Mi, Yingqi; Luan, Fang; Wei, Lijie; Li, Qing; Dong, Fang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Zhang, Jingjing; Tan, Wenqiang; Mi, Yingqi; Luan, Fang; Wei, Lijie; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 作者部门 | 海岸带生物资源高效利用研究与发展中心 |
| 英文摘要 | The toxicity concerns associated with chemical fungicides currently on the market have resulted in an increased demand for alternative ecofriendly fungicides. As a biodegradable and biocompatible dietary fiber, inulin shows potential as such a compound, given its lack of toxicity. In the current study, seven novel inulin derivatives with promising antifungal activity (BUCAIL, 2CBUCAIL, 3CBUCAIL, 4CBUCAIL, 3,4CBUCAIL, 2FBUCAIL, and 2BBUCAIL) are synthesized via condensation reactions of chloroacetyl inulin (CAIL) with urea groups bearing 4-amino-pyridine. Their structures are confirmed using FT-IR, H-1 NMR, C-13 NMR, and elemental analysis. Their antifungal activity against three kinds of phytopathogen (Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Fusarium oxysporum f. sp. cucumebrium Owen) is evaluated using the mycelial growth rate in vitro at concentrations of 0.10, 0.25, 0.50, 0.75, and 1.0 mg mL(-1). Results reveal that all seven inulin derivatives show improved antifungal properties compared with unmodified inulin, and two obvious inhibition rules are found: 3,4CBUCAIL > 4CBUCAIL > 3CBUCAIL > 2CBUCAIL > BUCAIL > CAIL > inulin and 2FBUCAIL > 2CBUCAIL > 2BBUCAIL > BUCAIL > CAIL > inulin. Thus, the introduction of urea groups into inulin derivatives could be key to increasing the antifungal activity of such compounds. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | ANTIBACTERIAL ACTIVITY ; ANTIOXIDANT ; COMPLEXES ; ESTERS |
| 研究领域[WOS] | Food Science & Technology |
| WOS记录号 | WOS:000454708500012 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24608 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jingjing,Tan, Wenqiang,Mi, Yingqi,et al. Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity[J]. STARCH-STARKE,2019,71(1-2):1800058-. |
| APA | Zhang, Jingjing.,Tan, Wenqiang.,Mi, Yingqi.,Luan, Fang.,Wei, Lijie.,...&Guo, Zhanyong.(2019).Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity.STARCH-STARKE,71(1-2),1800058-. |
| MLA | Zhang, Jingjing,et al."Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity".STARCH-STARKE 71.1-2(2019):1800058-. |
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