Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives
Luan, Fang; Wei, Lijie; Zhang, Jingjing; Tan, Wenqiang; Chen, Yuan; Wang, Ping; Dong, Fang; Li, Qing; Guo, Zhanyong
Source PublicationSTARCH-STARKE
ISSN0038-9056
2018-11
Volume70Issue:11-12Pages:1800026
Keywordantifungal activity N-diquaternized chitin N-quaternized chitin quaternary ammonium salt
MOST Discipline CatalogueFood Science & Technology
DOI10.1002/star.201800026
Contribution Rank[Luan, Fang; Wei, Lijie; Zhang, Jingjing; Tan, Wenqiang; Chen, Yuan; Dong, Fang; Li, Qing; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Luan, Fang; Wei, Lijie; Zhang, Jingjing; Tan, Wenqiang; Chen, Yuan; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wang, Ping] Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China
Department海岸带生物资源高效利用研究与发展中心
AbstractTo improve the bioactivity of chitin (CT), novel N-quaternized (QCT), and N-diquaternized (DQCT) CT derivatives are synthesized through a series of reactions from CT. The derivatives are characterized using elemental analysis, FTIR, and C-13 NMR. In addition, the inhibitory effects of the compounds against three fungi (B. cinerea, F. oxysporum, and P. asparagi) are tested. The inhibitory indices of CT, QCT, and DQCT are 12-15%, 63-73%, and 74-89%, respectively, at 1.0 mg mL(-1). The antifungal activities are in the order of DQCT > QCT > CT, which correlated with the number of quaternized groups. Based on these results, it is concluded that the antifungal activity of CT is improved by the introduction of quaternized groups on CT backbone.
SubtypeArticle
Funding OrganizationNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of China [ZR2017BD015] ; Yantai Science and Technology Development Plan [2015ZH078, 2015418022-3] ; Technology Research Funds Projects of Ocean [2015418022-3]
Indexed BySCI
Language英语
WOS KeywordFACILE CHEMICAL-MODIFICATIONS ; CHITOSAN DERIVATIVES ; ANTIBACTERIAL ACTIVITY ; ANTIOXIDANT ACTIVITIES ; ANTIMICROBIAL ACTIVITY ; BETA-CHITIN ; IN-VITRO ; EXTRACTION ; PRECURSORS
WOS Research AreaFood Science & Technology
WOS IDWOS:000449763300030
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/24564
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心
海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
Affiliation1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
3.Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China
Recommended Citation
GB/T 7714
Luan, Fang,Wei, Lijie,Zhang, Jingjing,et al. Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives[J]. STARCH-STARKE,2018,70(11-12):1800026.
APA Luan, Fang.,Wei, Lijie.,Zhang, Jingjing.,Tan, Wenqiang.,Chen, Yuan.,...&Guo, Zhanyong.(2018).Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives.STARCH-STARKE,70(11-12),1800026.
MLA Luan, Fang,et al."Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives".STARCH-STARKE 70.11-12(2018):1800026.
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