| Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives | |
Luan, Fang; Wei, Lijie; Zhang, Jingjing; Tan, Wenqiang ; Chen, Yuan; Wang, Ping; Dong, Fang; Li, Qing; Guo, Zhanyong
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| Source Publication | STARCH-STARKE
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| ISSN | 0038-9056 |
| 2018-11 | |
| Volume | 70Issue:11-12Pages:1800026 |
| Keyword | antifungal activity N-diquaternized chitin N-quaternized chitin quaternary ammonium salt |
| MOST Discipline Catalogue | Food Science & Technology |
| DOI | 10.1002/star.201800026 |
| Contribution Rank | [Luan, Fang; Wei, Lijie; Zhang, Jingjing; Tan, Wenqiang; Chen, Yuan; Dong, Fang; Li, Qing; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; [Luan, Fang; Wei, Lijie; Zhang, Jingjing; Tan, Wenqiang; Chen, Yuan; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wang, Ping] Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China |
| Department | 海岸带生物资源高效利用研究与发展中心 |
| Abstract | To improve the bioactivity of chitin (CT), novel N-quaternized (QCT), and N-diquaternized (DQCT) CT derivatives are synthesized through a series of reactions from CT. The derivatives are characterized using elemental analysis, FTIR, and C-13 NMR. In addition, the inhibitory effects of the compounds against three fungi (B. cinerea, F. oxysporum, and P. asparagi) are tested. The inhibitory indices of CT, QCT, and DQCT are 12-15%, 63-73%, and 74-89%, respectively, at 1.0 mg mL(-1). The antifungal activities are in the order of DQCT > QCT > CT, which correlated with the number of quaternized groups. Based on these results, it is concluded that the antifungal activity of CT is improved by the introduction of quaternized groups on CT backbone. |
| Subtype | Article |
| Funding Organization | National Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of China [ZR2017BD015] ; Yantai Science and Technology Development Plan [2015ZH078, 2015418022-3] ; Technology Research Funds Projects of Ocean [2015418022-3] |
| Indexed By | SCI |
| Language | 英语 |
| WOS Keyword | FACILE CHEMICAL-MODIFICATIONS ; CHITOSAN DERIVATIVES ; ANTIBACTERIAL ACTIVITY ; ANTIOXIDANT ACTIVITIES ; ANTIMICROBIAL ACTIVITY ; BETA-CHITIN ; IN-VITRO ; EXTRACTION ; PRECURSORS |
| WOS Research Area | Food Science & Technology |
| WOS ID | WOS:000449763300030 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/24564 |
| Collection | 海岸带生物学与生物资源利用重点实验室_海岸带生物资源高效利用研究与发展中心 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 中科院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| Affiliation | 1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Binzhou Med Univ Hosp, Dept Infect Dis, Binzhou 256603, Peoples R China |
| Recommended Citation GB/T 7714 | Luan, Fang,Wei, Lijie,Zhang, Jingjing,et al. Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives[J]. STARCH-STARKE,2018,70(11-12):1800026. |
| APA | Luan, Fang.,Wei, Lijie.,Zhang, Jingjing.,Tan, Wenqiang.,Chen, Yuan.,...&Guo, Zhanyong.(2018).Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives.STARCH-STARKE,70(11-12),1800026. |
| MLA | Luan, Fang,et al."Synthesis, Characterization, and Antifungal Activity of N-Quaternized and N-Diquaternized Chitin Derivatives".STARCH-STARKE 70.11-12(2018):1800026. |
| Files in This Item: | ||||||
| File Name/Size | DocType | Version | Access | License | ||
| Synthesis, Character（1938KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Application Full Text | |
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