| Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species | |
Liang, RN ; Ding, JW; Gao, SS; Qin, W
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| 发表期刊 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
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| ISSN | 1433-7851 |
| 2017-06-06 | |
| 卷号 | 56期号:24页码:6833-6837 |
| 关键词 | biological species biosensors imprinting mussel-inspired polymers potentiometry |
| 研究领域 | Chemistry, Multidisciplinary |
| DOI | 10.1002/anie.201701892 |
| 作者部门 | 海岸带环境过程实验室 |
| 英文摘要 | Using sensors to quantify clinically relevant biological species has emerged as a fascinating research field due to their potential to revolutionize clinical diagnosis and therapeutic monitoring. Taking advantage of the wide utility in clinical analysis and low cost of potentiometric ion sensors, we demonstrate a method to use such ion sensors to quantify bioanalytes without chemical labels. This is achieved by combination of chronopotentiometry with a mussel-inspired surface imprinting technique. The biomimetic sensing method is based on a blocking mechanism by which the recognition reaction between the surface imprinted polymer and a bioanalyte can block the current-induced ion transfer of an indicator ion, thus causing a potential change. The present method offers high sensitivity and excellent selectivity for detection of biological analytes. As models, trypsin and yeast cells can be measured at levels down to 0.03 UmL(-1) and 50 CFUmL(-1), respectively. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China [21475148, 41576106, 41206087] ; Science and Technology Project of Yantai [2014ZH086] ; Youth Innovation Promotion Association of CAS [2014190] ; Taishan Scholar Program of Shandong Province [TS20081159] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | biological species ; biosensors ; imprinting ; mussel-inspired polymers ; potentiometry |
| 研究领域[WOS] | Chemistry |
| WOS记录号 | WOS:000402523900023 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/24364 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_海岸带环境过程实验室 中国科学院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Shandong Prov Key Lab Coastal Environm Proc, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Shandong, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, RN,Ding, JW,Gao, SS,et al. Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2017,56(24):6833-6837. |
| APA | Liang, RN,Ding, JW,Gao, SS,&Qin, W.(2017).Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,56(24),6833-6837. |
| MLA | Liang, RN,et al."Mussel-Inspired Surface-Imprinted Sensors for Potentiometric Label-Free Detection of Biological Species".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56.24(2017):6833-6837. |
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| Mussel-Inspired Surf（1463KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | 浏览 下载 | |
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