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题名:
Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
作者: Gao, Min1,2; Yu FaBiao(于法标)1,3; Lv, Changjun3; Choo, Jaebum4; Chen, Lingxin1,3
刊名: CHEMICAL SOCIETY REVIEWS
ISSN号: 0306-0012
出版日期: 2017-04-21
卷号: 46, 期号:8, 页码:2237-2271
关键词: NEAR-INFRARED FLUORESCENCE ; AGGREGATION-INDUCED-EMISSION ; CARBONIC-ANHYDRASE-IX ; GROWTH-FACTOR RECEPTOR ; CHOLECYSTOKININ-B/GASTRIN RECEPTORS ; THERANOSTIC PLATINUM(IV) PRODRUG ; OPTICAL IMAGING PROBES ; MEMBRANE ANTIGEN PSMA ; LOW-MOLECULAR-WEIGHT ; BREAST-CANCER CELLS
学科分类: Chemistry
DOI: 10.1039/c6cs00908e
产权排序: [Gao, Min; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Gao, Min] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Yu, Fabiao; Lv, Changjun; Chen, Lingxin] Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou 256603, Peoples R China; [Choo, Jaebum] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea
通讯作者: Yu, FB
作者部门: 中科院海岸带环境过程与生态修复重点实验室
英文摘要: Surgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.
研究领域[WOS]: Chemistry
项目资助者: National Nature Science Foundation of China(21405172 ; National Research Foundation of Korea(2008-0061891 ; Korea Health Industry Development Institute(HI16C2129) ; program of Youth Innovation Promotion Association, CAS(2015170) ; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Scienc-es, CAS(KF2016-22) ; 21575159 ; 2009-00426) ; 31470415 ; 81670064)
关键词[WOS]: NEAR-INFRARED FLUORESCENCE ; AGGREGATION-INDUCED-EMISSION ; CARBONIC-ANHYDRASE-IX ; GROWTH-FACTOR RECEPTOR ; CHOLECYSTOKININ-B/GASTRIN RECEPTORS ; THERANOSTIC PLATINUM(IV) PRODRUG ; OPTICAL IMAGING PROBES ; MEMBRANE ANTIGEN PSMA ; LOW-MOLECULAR-WEIGHT ; BREAST-CANCER CELLS
文章类型: Review
收录类别: SCI
原文出处: 查看原文
语种: 英语
WOS记录号: WOS:000399389600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.yic.ac.cn/handle/133337/22054
Appears in Collections:中科院海岸带环境过程与生态修复重点实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou 256603, Peoples R China
4.Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea

Recommended Citation:
Gao, Min,Yu, Fabiao,Lv, Changjun,et al. Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy[J]. CHEMICAL SOCIETY REVIEWS,2017,46(8):2237-2271.
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