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Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy
Gao, Min1,2; Yu, Fabiao1,3; Lv, Changjun3; Choo, Jaebum4; Chen, Lingxin1,3; Yu, FB
2017-04-21
Source PublicationCHEMICAL SOCIETY REVIEWS
ISSN0306-0012
Volume46Issue:8Pages:2237-2271
Contribution Rank[Gao, Min; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; [Gao, Min] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Yu, Fabiao; Lv, Changjun; Chen, Lingxin] Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou 256603, Peoples R China; [Choo, Jaebum] Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea
AbstractSurgical resection of solid tumors is currently the gold standard and preferred therapeutic strategy for cancer. Chemotherapy drugs also make a significant contribution by inhibiting the rapid growth of tumor cells and these two approaches are often combined to enhance treatment efficacy. However, surgery and chemotherapy inevitably lead to severe side effects and high systemic toxicity, which in turn results in poor prognosis. Precision medicine has promoted the development of treatment modalities that are developed to specifically target and kill tumor cells. Advances in in vivo medical imaging for visualizing tumor lesions can aid diagnosis, facilitate surgical resection, investigate therapeutic efficacy, and improve prognosis. In particular, the modality of fluorescence imaging has high specificity and sensitivity and has been utilized for medical imaging. Therefore, there are great opportunities for chemists and physicians to conceive, synthesize, and exploit new chemical probes that can image tumors and release chemotherapy drugs in vivo. This review focuses on small molecular ligand-targeted fluorescent imaging probes and fluorescent theranostics, including their design strategies and applications in clinical tumor treatment. The progress in chemical probes described here suggests that fluorescence imaging is a vital and rapidly developing field for interventional surgical imaging, as well as tumor diagnosis and therapy.
KeywordNear-infrared Fluorescence Aggregation-induced-emission Carbonic-anhydrase-ix Growth-factor Receptor Cholecystokinin-b/gastrin Receptors Theranostic Platinum(Iv) Prodrug Optical Imaging Probes Membrane Antigen Psma Low-molecular-weight Breast-cancer Cells
Department中科院海岸带环境过程与生态修复重点实验室
Subject AreaChemistry
DOI10.1039/c6cs00908e
Funding OrganizationNational Nature Science Foundation of China(21405172 ; National Research Foundation of Korea(2008-0061891 ; Korea Health Industry Development Institute(HI16C2129) ; program of Youth Innovation Promotion Association, CAS(2015170) ; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Scienc-es, CAS(KF2016-22) ; 21575159 ; 2009-00426) ; 31470415 ; 81670064)
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Indexed BySCI
WOS KeywordNEAR-INFRARED FLUORESCENCE ; AGGREGATION-INDUCED-EMISSION ; CARBONIC-ANHYDRASE-IX ; GROWTH-FACTOR RECEPTOR ; CHOLECYSTOKININ-B/GASTRIN RECEPTORS ; THERANOSTIC PLATINUM(IV) PRODRUG ; OPTICAL IMAGING PROBES ; MEMBRANE ANTIGEN PSMA ; LOW-MOLECULAR-WEIGHT ; BREAST-CANCER CELLS
SubtypeReview
Language英语
WOS Research AreaChemistry
WOS IDWOS:000399389600008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/22054
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorYu, FB
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Binzhou Med Univ, Dept Resp Med, Affiliated Hosp, Binzhou 256603, Peoples R China
4.Hanyang Univ, Dept Bionano Engn, Ansan 426791, South Korea
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Gao, Min,Yu, Fabiao,Lv, Changjun,et al. Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy[J]. CHEMICAL SOCIETY REVIEWS,2017,46(8):2237-2271.
APA Gao, Min,Yu, Fabiao,Lv, Changjun,Choo, Jaebum,Chen, Lingxin,&Yu, FB.(2017).Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy.CHEMICAL SOCIETY REVIEWS,46(8),2237-2271.
MLA Gao, Min,et al."Fluorescent chemical probes for accurate tumor diagnosis and targeting therapy".CHEMICAL SOCIETY REVIEWS 46.8(2017):2237-2271.
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