| HAL2 overexpression induces iron acquisition in bdf1 Delta cells and enhances their salt resistance | |
Chen, Lei1,2; Wang, Mingpeng1,3; Hou, Jin1; Fu, Jiafang1; Shen, Yu1; Liu, Fanghua2 ; Zhang, Zhaojie4; Bao, Xiaoming1; Bao, XM (reprint author), Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China. bxm@sdu.edu.cn
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| 发表期刊 | CURRENT GENETICS
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| ISSN | 0172-8083 |
| 2017-05-01 | |
| 卷号 | 63期号:2页码:229-239 |
| 关键词 | Bromodomain Factor 1 Iron Acquisition Hal2 Hda1 Salt Stress Response |
| DOI | 10.1007/s00294-016-0628-9 |
| 产权排序 | [Chen, Lei; Wang, Mingpeng; Hou, Jin; Fu, Jiafang; Shen, Yu; Bao, Xiaoming] Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China; [Chen, Lei; Liu, Fanghua] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China; [Wang, Mingpeng] Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150090, Peoples R China; [Zhang, Zhaojie] Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA |
| 作者部门 | 海岸带生物学与生物资源利用所重点实验室 |
| 英文摘要 | The yeast Saccharomyces cerevisiae is capable of responding to various environmental stresses, such as salt stress. Such responses require a complex network and adjustment of the gene expression network. The goal of this study is to further understand the molecular mechanism of salt stress response in yeast, especially the molecular mechanism related to genes BDF1 and HAL2. The Bromodomain Factor 1 (Bdf1p) is a transcriptional regulator, which is part of the basal transcription factor TFIID. Cells lacking Bdf1p are salt sensitive with an abnormal mitochondrial function. We previously reported that the overexpression of HAL2 or deletion of HDA1 lowers the salt sensitivity of bdf1 Delta. To better understand the mechanism behind the HAL2-related response to salt stress, we compared three global transcriptional profiles (bdf1 Delta vs WT, bdf1 Delta + HAL2 vs bdf1 Delta, and bdf1 Delta hda1 Delta vs bdf1 Delta) in response to salt stress using DNA microarrays. Our results reveal that genes for iron acquisition and cellular and mitochondrial remodeling are induced by HAL2. Overexpression of HAL2 decreases the concentration of nitric oxide. Mitochondrial iron-sulfur cluster (ISC) assembly also decreases in bdf1 Delta + HAL2. These changes are similar to the changes of transcriptional profiles induced by iron starvation. Taken together, our data suggest that mitochondrial functions and iron homeostasis play an important role in bdf1 Delta-induced salt sensitivity and salt stress response in yeast. |
| 文章类型 | Article |
| 资助机构 | National Natural Science Foundation of China(41401285 ; Open Foundation of State Key Laboratory of Estuarine and Coastal Research(SKLEC-KF201412) ; 30170021 ; 30671143 ; 30570031 ; 41371257 ; 41573071) |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | SACCHAROMYCES-CEREVISIAE ; NITRIC-OXIDE ; MITOCHONDRIAL-FUNCTION ; CYTOCHROME-C ; YEAST ; EXPRESSION ; STRESS ; BDF1 ; GENE ; NUCLEOTIDASE |
| 研究领域[WOS] | Genetics & Heredity |
| WOS记录号 | WOS:000399176400009 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/22034 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 通讯作者 | Bao, XM (reprint author), Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China. bxm@sdu.edu.cn |
| 作者单位 | 1.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China 3.Harbin Inst Technol, Sch Municipal & Environm Engn, Harbin 150090, Peoples R China 4.Univ Wyoming, Dept Zool & Physiol, Laramie, WY 82071 USA |
| 推荐引用方式 GB/T 7714 | Chen, Lei,Wang, Mingpeng,Hou, Jin,et al. HAL2 overexpression induces iron acquisition in bdf1 Delta cells and enhances their salt resistance[J]. CURRENT GENETICS,2017,63(2):229-239. |
| APA | Chen, Lei.,Wang, Mingpeng.,Hou, Jin.,Fu, Jiafang.,Shen, Yu.,...&Bao, XM .(2017).HAL2 overexpression induces iron acquisition in bdf1 Delta cells and enhances their salt resistance.CURRENT GENETICS,63(2),229-239. |
| MLA | Chen, Lei,et al."HAL2 overexpression induces iron acquisition in bdf1 Delta cells and enhances their salt resistance".CURRENT GENETICS 63.2(2017):229-239. |
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