抗生素抗性基因(antibiotic resistance genes,ARGs)作为一种新型的环境污染物,成为多个学科关注的焦点.其在不同环境介质中的扩散和传播具有极大的环境危害性,对人类健康造成严重威胁.插入序列共同区(insertion sequence common region,ISCR),是一种新发现的抗性基因传播元件,因其特殊的遗传结构,能够通过滚环复制及同源重组等机制移动邻近的任何DNA序列,是ARGs在不同DNA分子或不同种属细菌间水平传播的高效媒介.目前世界上发现了27种ISCR元件.大量间接证据表明,ISCR可能与许多耐药基因的移动和扩散有关,特别是多重耐药性(multi...
中文摘要
Antibiotic resistance genes ( AＲGs) as emerging environmental pollutants have become the focus of attention of many disciplines． The transmission and dissemination of AＲGs in various environmental media has great hazards to environment and poses serious threat to human health． ISCＲ ( insertion sequence common regions) elements are newly discovered resistance genes transmission elements． Because of the special genetic structure，ISCＲ elements can move any adjacent DNA sequences by rolling-circle replication and homologous recombination，and have become the efficient transmission elements of AＲGs among different DNA molecules or bacterial species． Around the world，27 members of the ISCＲ family have been discovered up to now． A lot of circumstantial evidence has indicated that ISCＲ elements may be associated with the mobility and transmission of kinds of AＲGs，especially multiple drug resistance genes ( MDＲ) ． In this review，we described some aspects of ISCＲ elements，including the horizontal transfer of AＲGs，structural characteristics of ISCＲs，classification of ISCＲs and their related AＲGs，research methods of these elements，possible ecological risk of ISCＲs and proposal of research directions，hoping to provide help for further related research in the future．
; 李宝泉
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