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A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles
Li, LZ; Wu, HF; Ji, CL; van Gestel, CAM; Allen, HE; Peijnenburg, WJGM; Wu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Environm Proc,YICCA, 17,Chunhui Rd, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
Source PublicationECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
ISSN0147-6513
2015-09
Volume119Pages:66-73
KeywordDaphnia Magna Silver Nanoparticle Metabolomics Silver Ion Sublethal Toxicity
DOI10.1016/j.ecoenv.2015.05.005
Contribution Rank[Li, LianZhen; Wu, Huifeng; Ji, Chenglong] Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Environm Proc,YICCA, Yantai 264003, Shandong, Peoples R China; [van Gestel, Cornelis A. M.] Vrije Univ Amsterdam, Fac Earth & Life Sci, Dept Ecol Sci, NL-1081 HV Amsterdam, Netherlands; [Allen, Herbert E.] Univ Delaware, Dept Civil & Environm Engn, Newark, DE 19716 USA; [Peijnenburg, Willie J. G. M.] Natl Inst Publ Hlth & Environm, Ctr Safety Subst & Prod, NL-3720 BA Bilthoven, Netherlands; [Peijnenburg, Willie J. G. M.] Leiden Univ, Inst Environm Sci CML, Leiden, Netherlands
Department中科院海岸带环境过程与生态修复重点实验室
AbstractWe examined the short-term toxicity of AgNPs and AgNO3 to Daphnia magna at sublethal levels using H-1 NMR-based metabolomics. Two sizes of polyvinylpyrrolidone-coated AgNPs (10 and 40 nm) were synthesized and characterized and their Ag+ release was studied using centrifugal ultrafiltration and inductively coupled plasma mass spectrometry. Multivariate statistical analysis of the H-1 NMR spectra showed significant changes in the D. magna metabolic profiles following 48 h exposure to both AgNP particle sizes and Ag+ exposure. Most of the metabolic biomarkers for AgNP exposure, including 3-hydroxybutyrate, arginine, lysine and phosphocholine, were identical to those of the Ag+-exposed groups, suggesting that the dominant effects of both AgNPs were due to released Ag+. The observed metabolic changes implied that the released Ag+ induced disturbance in energy metabolism and oxidative stress, a proposed mechanism of AgNP toxicity. Elevated levels of lactate in all AgNP-treated but not in Ag+-treated groups provided evidence for Ag-NP enhanced anaerobic metabolism. These findings show that H-1 NMR-based metabolomics provides a sensitive measure of D. magna response to AgNPs and that further targeted assays are needed to elucidate mechanisms of action of nanoparticle-induced toxicity. (C) 2015 Elsevier Inc. All rights reserved.
Subtype期刊论文
Indexed BySCI
Language英语
WOS KeywordTOXICITY ; NMR ; EXTRACTION ; ORGANISMS ; STRESS ; ACID ; RATS
WOS Research AreaEnvironmental Sciences ; Toxicology
WOS IDWOS:000356841200008
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/13813
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorWu, HF (reprint author), Chinese Acad Sci, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Shandong Prov Key Lab Coastal Environm Proc,YICCA, 17,Chunhui Rd, Yantai 264003, Shandong, Peoples R China. hfwu@yic.ac.cn
Recommended Citation
GB/T 7714
Li, LZ,Wu, HF,Ji, CL,et al. A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2015,119:66-73.
APA Li, LZ.,Wu, HF.,Ji, CL.,van Gestel, CAM.,Allen, HE.,...&Wu, HF .(2015).A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,119,66-73.
MLA Li, LZ,et al."A metabolomic study on the responses of daphnia magna exposed to silver nitrate and coated silver nanoparticles".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 119(2015):66-73.
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