Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe
Jing, Xiaotong1,2; Yu, Fabiao2; Chen, Lingxin1,2; Chen, LX (reprint author), Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China. lxchen@yic.ac.cn
发表期刊CHEMICAL COMMUNICATIONS
ISSN1359-7345
2014
卷号50期号:91页码:14253-14256
关键词Nitric-oxide Living Cells Reductant-resistant Aqueous-solution Reactive Oxygen No Production Chemistry Ligation Complex Ph
DOI10.1039/c4cc07561g
产权排序[Jing, Xiaotong; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Jing, Xiaotong; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
作者部门中科院海岸带环境过程与生态修复重点实验室
英文摘要We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice.; We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice.
文章类型Article
资助机构Chemistry
收录类别SCI ; IC
语种英语
关键词[WOS]NITRIC-OXIDE ; LIVING CELLS ; REDUCTANT-RESISTANT ; AQUEOUS-SOLUTION ; REACTIVE OXYGEN ; NO PRODUCTION ; CHEMISTRY ; LIGATION ; COMPLEX ; PH
研究领域[WOS]Chemistry
WOS记录号WOS:000344226000046
引用统计
被引频次:118[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/8775
专题中国科学院海岸带环境过程与生态修复重点实验室
通讯作者Chen, LX (reprint author), Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China. lxchen@yic.ac.cn
作者单位1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
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GB/T 7714
Jing, Xiaotong,Yu, Fabiao,Chen, Lingxin,et al. Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe[J]. CHEMICAL COMMUNICATIONS,2014,50(91):14253-14256.
APA Jing, Xiaotong,Yu, Fabiao,Chen, Lingxin,&Chen, LX .(2014).Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe.CHEMICAL COMMUNICATIONS,50(91),14253-14256.
MLA Jing, Xiaotong,et al."Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe".CHEMICAL COMMUNICATIONS 50.91(2014):14253-14256.
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