Institutional Repository of Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences (KLCEP)
Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe | |
Jing, Xiaotong1,2; Yu, Fabiao2; Chen, Lingxin1,2; Chen, LX (reprint author), Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China. lxchen@yic.ac.cn | |
发表期刊 | CHEMICAL COMMUNICATIONS |
ISSN | 1359-7345 |
2014 | |
卷号 | 50期号:91页码:14253-14256 |
关键词 | Nitric-oxide Living Cells Reductant-resistant Aqueous-solution Reactive Oxygen No Production Chemistry Ligation Complex Ph |
DOI | 10.1039/c4cc07561g |
产权排序 | [Jing, Xiaotong; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Jing, Xiaotong; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
作者部门 | 中科院海岸带环境过程与生态修复重点实验室 |
英文摘要 | We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice.; We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice. |
文章类型 | Article |
资助机构 | Chemistry |
收录类别 | SCI ; IC |
语种 | 英语 |
关键词[WOS] | NITRIC-OXIDE ; LIVING CELLS ; REDUCTANT-RESISTANT ; AQUEOUS-SOLUTION ; REACTIVE OXYGEN ; NO PRODUCTION ; CHEMISTRY ; LIGATION ; COMPLEX ; PH |
研究领域[WOS] | Chemistry |
WOS记录号 | WOS:000344226000046 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.yic.ac.cn/handle/133337/8775 |
专题 | 中国科学院海岸带环境过程与生态修复重点实验室 |
通讯作者 | Chen, LX (reprint author), Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China. lxchen@yic.ac.cn |
作者单位 | 1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China |
推荐引用方式 GB/T 7714 | Jing, Xiaotong,Yu, Fabiao,Chen, Lingxin,et al. Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe[J]. CHEMICAL COMMUNICATIONS,2014,50(91):14253-14256. |
APA | Jing, Xiaotong,Yu, Fabiao,Chen, Lingxin,&Chen, LX .(2014).Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe.CHEMICAL COMMUNICATIONS,50(91),14253-14256. |
MLA | Jing, Xiaotong,et al."Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe".CHEMICAL COMMUNICATIONS 50.91(2014):14253-14256. |
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