YIC-IR  > 中科院海岸带环境过程与生态修复重点实验室
Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe
Jing, Xiaotong1,2; Yu, Fabiao2; Chen, Lingxin1,2; Chen, LX (reprint author), Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China. lxchen@yic.ac.cn
2014
Source PublicationCHEMICAL COMMUNICATIONS
ISSN1359-7345
Volume50Issue:91Pages:14253-14256
Contribution Rank[Jing, Xiaotong; Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China; [Jing, Xiaotong; Yu, Fabiao; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
AbstractWe have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice.; We have presented a near-infrared fluorescent probe Lyso-JN for the detection of nitroxyl (HNO) in cells and in vivo. Lyso-JN is comprised of three moieties: an Aza-BODIPY fluorophore, a HNO-response modulator, diphenylphosphino-benzoyl, and a lysosomal locator, alkylmorpholine. The detection mechanism is based on aza-ylide intramolecular ester aminolysis reaction with HNO. The probe holds the ability to capture lysosomal HNO in RAW 264.7 cells, and it is also successfully employed to visualize HNO in mice.
KeywordNitric-oxide Living Cells Reductant-resistant Aqueous-solution Reactive Oxygen No Production Chemistry Ligation Complex Ph
Department中科院海岸带环境过程与生态修复重点实验室
Subject AreaChemistry, Multidisciplinary
DOI10.1039/c4cc07561g
Funding OrganizationChemistry
Indexed BySCI ; IC
WOS KeywordNITRIC-OXIDE ; LIVING CELLS ; REDUCTANT-RESISTANT ; AQUEOUS-SOLUTION ; REACTIVE OXYGEN ; NO PRODUCTION ; CHEMISTRY ; LIGATION ; COMPLEX ; PH
SubtypeArticle
Language英语
WOS Research AreaChemistry
WOS IDWOS:000344226000046
Citation statistics
Cited Times:94[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/8775
Collection中科院海岸带环境过程与生态修复重点实验室
Corresponding AuthorChen, LX (reprint author), Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China. lxchen@yic.ac.cn
Affiliation1.Qufu Normal Univ, Coll Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
First Author AffilicationYantai Institute of Coastal Zone Research, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Jing, Xiaotong,Yu, Fabiao,Chen, Lingxin,et al. Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe[J]. CHEMICAL COMMUNICATIONS,2014,50(91):14253-14256.
APA Jing, Xiaotong,Yu, Fabiao,Chen, Lingxin,&Chen, LX .(2014).Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe.CHEMICAL COMMUNICATIONS,50(91),14253-14256.
MLA Jing, Xiaotong,et al."Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe".CHEMICAL COMMUNICATIONS 50.91(2014):14253-14256.
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