Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity
Dong, Fang1; Zhang, Jun2; Yu, Chunwei2; Li, Qing1; Ren, Jianming1; Wang, Gang1; Gu, Guodong3; Guo, Zhanyong1; Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. zhanyongguo@hotmail.com
发表期刊BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
2014-09-15
卷号24期号:18页码:4590-4593
关键词Inulin Click Chemistry Selective Modification Reactive Precursor Antibacterial Activity
DOI10.1016/j.bmcl.2014.07.029
产权排序[Dong, Fang; Li, Qing; Ren, Jianming; Wang, Gang; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; [Zhang, Jun; Yu, Chunwei] Hainan Med Coll, Sch Trop & Lab Med, Environm Monitoring Lab, Haikou 571199, Peoples R China; [Gu, Guodong] Alliance Pharma Inc, Malvern, PA 19355 USA
作者部门海岸带生物学与生物资源利用所重点实验室
英文摘要Inulins are a group of abundant, water-soluble, renewable polysaccharides, which exhibit attractive bioactivities and natural properties. Improvement such as chemical modification of inulin is often performed prior to further utilization. We hereby presented a method to modify inulin at its primary hydroxyls to synthesize amphiphilic aminated inulin via 'click chemistry' to facilitate its chemical manipulation. Additionally, its antibacterial property against Staphylococcus aureus (S. aureus) was also evaluated and the best inhibitory index against S. aureus was 58% at 1 mg/mL. As the amphiphilic aminated inulin is easy to prepare and exhibits improved bioactivity, this material may represent as an attractive new platform for chemical modifications of inulin. (C) 2014 Elsevier Ltd. All rights reserved.
文章类型Article
资助机构12th Five-Year Science and Technology Plan for Agriculture 2012BAD32B09 ; Science and Technology Project of Yantai 20121321 ; Chemistry ; Taishan Scholar Program of Shandong Province
收录类别SCI
语种英语
关键词[WOS]CHITOSAN DERIVATIVES
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
WOS记录号WOS:000341435000046
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/8530
专题海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室
通讯作者Guo, ZY (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China. zhanyongguo@hotmail.com
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
2.Hainan Med Coll, Sch Trop & Lab Med, Environm Monitoring Lab, Haikou 571199, Peoples R China
3.Alliance Pharma Inc, Malvern, PA 19355 USA
推荐引用方式
GB/T 7714
Dong, Fang,Zhang, Jun,Yu, Chunwei,et al. Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(18):4590-4593.
APA Dong, Fang.,Zhang, Jun.,Yu, Chunwei.,Li, Qing.,Ren, Jianming.,...&Guo, ZY .(2014).Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(18),4590-4593.
MLA Dong, Fang,et al."Synthesis of amphiphilic aminated inulin via 'click chemistry' and evaluation for its antibacterial activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.18(2014):4590-4593.
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