| 羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究 | |
| Alternative Title | Antioxidant activities of vanadyl Carboxymethyl agaro-oligo-saccharides and its antiproliferation effects on BEL-7402 cancer cell line |
刘广洋; 冯大伟 ; 靳志明; 刘胜一; 衣悦涛; 衣悦涛. 中国科学院烟台海岸带研究所,山东,烟台,264003. Email; ytyi@yic.ac.cn
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| Source Publication | 海洋科学
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| ISSN | 1000-3096 |
| 2014 | |
| Volume | 38Issue:2Pages:34-38 |
| Keyword | 羧甲基 琼胶寡糖 钒络合物 抗氧化 Bel-7402癌细胞 |
| Contribution Rank | 中国科学院烟台海岸带研究所 |
| Department | 海岸带生物学与生物资源利用所重点实验室 |
| Abstract | 制备了羧甲基琼胶寡糖钒络合物,并利用ICP-MS测定钒的含量为4.6%;同时,对钒氧羧甲基琼胶寡糖抗氧化和抑制人肝癌BEL-7402细胞增殖活性进行研究。抗氧化实验结果表明,钒氧羧甲基琼胶寡糖清除OH的能力和DPPH的能力均比羧甲基琼胶寡糖的清除能力有显著提高。经磺酰罗丹明B蛋白染色法测试,进一步发现钒氧羧甲基琼胶寡糖在16~1000 mg/L浓度范围内对人肝癌BEL-7402细胞的增殖有较好的抑制作用。 |
| Other Abstract | The Vanadyl Carboxymethyl agaro-oligosaccharides were synthetized and the mass fraction of vanadium was 4.6 % determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The antioxidant activity of oxovanadium (IV) complexes was investigated in vitro. The results showed that both of the hydroxyl radical scav-enging and DPPH scavenging activities of the oxovanadium complexes were stronger than their ligands. Further-more, the potential antiproliferation activitiy of vanadyl Carboxymethyl agaro-oligosaccharides was evaluated in human hepatocellular carcinoma BEL-7402 cancer cell line. The results showed that the vanadyl Carboxymethyl agaro-oligosaccharides had significant inhibitory effects on cancer cell proliferation even at low concentrations. |
| Subtype | 期刊论文 |
| Indexed By | CSCD |
| Language | 中文 |
| WOS Research Area | 海洋科学 |
| CSCD ID | CSCD:5141214 |
| Funding Organization | 国家海洋局海洋公益性行业专项项目 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.yic.ac.cn/handle/133337/8355 |
| Collection | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| Corresponding Author | 衣悦涛. 中国科学院烟台海岸带研究所,山东,烟台,264003. Email; ytyi@yic.ac.cn |
| Affiliation | 中国科学院烟台海岸带研究所 |
| Recommended Citation GB/T 7714 | 刘广洋,冯大伟,靳志明,等. 羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究[J]. 海洋科学,2014,38(2):34-38. |
| APA | 刘广洋.,冯大伟.,靳志明.,刘胜一.,衣悦涛.,...&ytyi@yic.ac.cn.(2014).羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究.海洋科学,38(2),34-38. |
| MLA | 刘广洋,et al."羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究".海洋科学 38.2(2014):34-38. |
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