羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究
Alternative TitleAntioxidant activities of vanadyl Carboxymethyl agaro-oligo-saccharides and its antiproliferation effects on BEL-7402 cancer cell line
刘广洋; 冯大伟; 靳志明; 刘胜一; 衣悦涛; 衣悦涛. 中国科学院烟台海岸带研究所,山东,烟台,264003. Email; ytyi@yic.ac.cn
Source Publication海洋科学
ISSN1000-3096
2014
Volume38Issue:2Pages:34-38
Keyword羧甲基 琼胶寡糖 钒络合物 抗氧化 Bel-7402癌细胞
Contribution Rank中国科学院烟台海岸带研究所
Department海岸带生物学与生物资源利用所重点实验室
Abstract制备了羧甲基琼胶寡糖钒络合物,并利用ICP-MS测定钒的含量为4.6%;同时,对钒氧羧甲基琼胶寡糖抗氧化和抑制人肝癌BEL-7402细胞增殖活性进行研究。抗氧化实验结果表明,钒氧羧甲基琼胶寡糖清除OH的能力和DPPH的能力均比羧甲基琼胶寡糖的清除能力有显著提高。经磺酰罗丹明B蛋白染色法测试,进一步发现钒氧羧甲基琼胶寡糖在16~1000 mg/L浓度范围内对人肝癌BEL-7402细胞的增殖有较好的抑制作用。
Other AbstractThe Vanadyl Carboxymethyl agaro-oligosaccharides were synthetized and the mass fraction of vanadium was 4.6 % determined by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). The antioxidant activity of oxovanadium (IV) complexes was investigated in vitro. The results showed that both of the hydroxyl radical scav-enging and DPPH scavenging activities of the oxovanadium complexes were stronger than their ligands. Further-more, the potential antiproliferation activitiy of vanadyl Carboxymethyl agaro-oligosaccharides was evaluated in human hepatocellular carcinoma BEL-7402 cancer cell line. The results showed that the vanadyl Carboxymethyl agaro-oligosaccharides had significant inhibitory effects on cancer cell proliferation even at low concentrations.
Subtype期刊论文
Indexed ByCSCD
Language中文
WOS Research Area海洋科学
CSCD IDCSCD:5141214
Funding Organization国家海洋局海洋公益性行业专项项目
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Document Type期刊论文
Identifierhttp://ir.yic.ac.cn/handle/133337/8355
Collection海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室
Corresponding Author衣悦涛. 中国科学院烟台海岸带研究所,山东,烟台,264003. Email; ytyi@yic.ac.cn
Affiliation中国科学院烟台海岸带研究所
Recommended Citation
GB/T 7714
刘广洋,冯大伟,靳志明,等. 羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究[J]. 海洋科学,2014,38(2):34-38.
APA 刘广洋.,冯大伟.,靳志明.,刘胜一.,衣悦涛.,...&ytyi@yic.ac.cn.(2014).羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究.海洋科学,38(2),34-38.
MLA 刘广洋,et al."羧甲基琼胶寡糖钒络合物抗氧化及抑制BEL-7402癌细胞增殖的研究".海洋科学 38.2(2014):34-38.
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