Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect
Lin, Donghai1; Qin, Tianqi1; Wang, Yunqing2; Sun, Xiuyan1; Chen, Lingxin2
2014-01-22
发表期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
卷号6期号:2页码:1320-1329
产权排序[Lin, Donghai; Qin, Tianqi; Sun, Xiuyan] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; [Wang, Yunqing; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
摘要As novel optical nanoprobes, surface-enhanced Raman scattering (SERS) tags have drawn growing interests in the application of biomedical imaging and phototherapies. Herein, we demonstrated a novel in situ synthesis strategy for GO wrapped gold nanocluster SERS tags by using a tris(2,2'-bipyridyl)ruthenium-(II) chloride (Rubpy)/GO nanohybrid as a complex Raman reporter, inspired by the role of GO as an artificial receptor for various dyes. The introduction of GO in the synthesis procedure provided systematic solutions for controlling several key parameters of SERS tags, including reproducibility, sensitivity, and colloidal and signal stability. An additional interesting thermal-sensitive SERS property (SERS intensity decreased upon increasing the temperature) was also achieved due to the heat-induced release/redistribution of reporter molecules adsorbed on GO. Combining the synergic effect of these features, we further fabricated multifunctional, aldehyde group conjugated Au@Rubpy/GO SEAS tags for optical labeling and photothermal ablation of bacteria. Sensitive Raman imaging of gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria could be realized, and satisfactory photothermal killing efficacy for both bacteria was achieved. Our results also demonstrated the correlation among the SEAS intensity decrease ratio, bacteria survival rate, and the terminal temperature of the tag-bacteria suspension, showing the possibility to use SERS assay to measure antibacterial response during the photothermal process using this tag.; As novel optical nanoprobes, surface-enhanced Raman scattering (SERS) tags have drawn growing interests in the application of biomedical imaging and phototherapies. Herein, we demonstrated a novel in situ synthesis strategy for GO wrapped gold nanocluster SERS tags by using a tris(2,2'-bipyridyl)ruthenium-(II) chloride (Rubpy)/GO nanohybrid as a complex Raman reporter, inspired by the role of GO as an artificial receptor for various dyes. The introduction of GO in the synthesis procedure provided systematic solutions for controlling several key parameters of SERS tags, including reproducibility, sensitivity, and colloidal and signal stability. An additional interesting thermal-sensitive SERS property (SERS intensity decreased upon increasing the temperature) was also achieved due to the heat-induced release/redistribution of reporter molecules adsorbed on GO. Combining the synergic effect of these features, we further fabricated multifunctional, aldehyde group conjugated Au@Rubpy/GO SEAS tags for optical labeling and photothermal ablation of bacteria. Sensitive Raman imaging of gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria could be realized, and satisfactory photothermal killing efficacy for both bacteria was achieved. Our results also demonstrated the correlation among the SEAS intensity decrease ratio, bacteria survival rate, and the terminal temperature of the tag-bacteria suspension, showing the possibility to use SERS assay to measure antibacterial response during the photothermal process using this tag.
通讯作者Wang, YQ (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China. yqwang@yic.ac.cn ; lxchen@yic.ac.cn
关键词Graphene Oxide Gold Nanoparticles Sers Tags Bacteria Photothermal Ablation
学科领域Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
项目资助者National Natural Science Foundation of China [81102415, 21275158]; Natural Science Foundation of Shandong Province of China [ZR2010BQ012]; Science and Technology Development Plan of Yantai [2011071]; One Hundred Person Project of the Chinese Academy of Sciences
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收录类别SCI
关键词[WOS]ENHANCED RAMAN-SCATTERING ; FUNCTIONALIZED SILVER NANOPARTICLES ; SHELL NANOPARTICLES ; GOLD NANOPARTICLES ; DRUG-DELIVERY ; SURFACE ; SPECTROSCOPY ; THERAPY ; ANTIAGGREGATION ; FABRICATION
文章类型Article
语种英语
资助项目中国科学院海岸带环境过程与生态修复重点实验室
WOS研究方向Science & Technology - Other Topics ; Materials Science
WOS记录号WOS:000330201900080
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被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.yic.ac.cn/handle/133337/6909
专题中科院海岸带环境过程与生态修复重点实验室
作者单位1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China
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Lin, Donghai,Qin, Tianqi,Wang, Yunqing,et al. Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect[J]. ACS APPLIED MATERIALS & INTERFACES,2014,6(2):1320-1329.
APA Lin, Donghai,Qin, Tianqi,Wang, Yunqing,Sun, Xiuyan,&Chen, Lingxin.(2014).Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect.ACS APPLIED MATERIALS & INTERFACES,6(2),1320-1329.
MLA Lin, Donghai,et al."Graphene Oxide Wrapped SERS Tags: Multifunctional Platforms toward Optical Labeling, Photothermal Ablation of Bacteria, and the Monitoring of Killing Effect".ACS APPLIED MATERIALS & INTERFACES 6.2(2014):1320-1329.
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