| Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics | |
| Zhang, L ; Liu, XL ; You, LP ; Zhou, D ; Wang, Q ; Li, F ; Cong, M ; Li, LZ ; Zhao, JM ; Liu, DY ; Yu, JB ; Wu, HF | |
| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| ISSN | 1382-6689 |
| 2011 | |
| 卷号 | 32期号:2页码:218-225 |
| 关键词 | Benzo(a)Pyrene Toxicological Effects Biomarker Manila Clam Nmr Metabolomics Pattern-recognition Nmr Metabolomics Tidal Flats Liver Spectroscopy Metabonomics Extraction Transformation Vitellogenin Biochemistry |
| 产权排序 | [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di; Wang, Qing; Li, Fei; Cong, Ming; Li, Lianzhen; Zhao, Jianmin; Liu, Dongyan; Yu, Junbao; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China; [Zhang, Linbao; Liu, Xiaoli; You, Liping; Zhou, Di] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 通讯作者 | Wu, HF (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Zone Environm Proc, Shandong Prov Key Lab Coastal Zone Environm Proc, Yantai 264003, Peoples R China |
| 作者部门 | 污染过程与控制实验室 |
| 英文摘要 | Benzo(a)pyrene is an important polycyclic aromatic hydrocarbon (PAH) which causes carcinogenic, teratogenic and mutagenic effects in various species and the level of contamination of this toxic agent in the marine environment is of great concern. In this study, metabolic responses induced by two doses (0.02 and 0.2 mu M) of BaP were characterized in the gill tissues of Manila clam Ruditapes philippinarum after exposure for 24, 48 and 96h. The high dose (0.2 mu M) of BaP induced the disturbances in energy metabolism and osmotic regulation based on the metabolic biomarkers such as succinate, alanine, glucose, glycogen, branched chain amino acids, betaine, taurine, homarine, and dimethylamine in clam gills after 24 h of exposure. In addition, hormesis induced by BaP was found in clams exposed to both doses of BaP. Overall, our results demonstrated the applicability of metabolomics for the elucidation of toxicological effects of marine environmental contaminants in a selected bioindicator species such as the Manila clam. (C) 2011 Elsevier B.V. All rights reserved. |
| 资助机构 | Chinese Academy of Sciences[KZCX2-YW-Q07-04]; Technology Development Program Projects of Shandong Province[2008GG20005006, 2008GG3NS0700]; SDSFC[ZR2009CZ008]; CAS/SAFEA |
| 收录类别 | SCI |
| 语种 | 英语 |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/5368 |
| 专题 | 中国科学院海岸带环境过程与生态修复重点实验室_污染过程与控制实验室 |
| 推荐引用方式 GB/T 7714 | Zhang, L,Liu, XL,You, LP,et al. Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2011,32(2):218-225. |
| APA | Zhang, L.,Liu, XL.,You, LP.,Zhou, D.,Wang, Q.,...&Wu, HF.(2011).Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,32(2),218-225. |
| MLA | Zhang, L,et al."Benzo(a)pyrene-induced metabolic responses in Manila clam Ruditapes philippinarum by proton nuclear magnetic resonance ((1)H NMR) based metabolomics".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 32.2(2011):218-225. |
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