| The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats | |
Sun, Yingxin1,2; Zhang, Juan3; Yan, Yongjian3; Chi, Mingfeng4; Chen, Wenwen3; Sun, Peng5; Qin, Song1,6
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| 发表期刊 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
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| ISSN | 1382-6689 |
| 2011-09-01 | |
| 卷号 | 32期号:2页码:168-174 |
| 关键词 | C-phycocyanin Paraquat Acute Lung Injury Lipid Peroxidation Inflammation |
| 产权排序 | [Sun, Yingxin; Qin, Song] Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China; [Sun, Yingxin] Shandong Univ Tradit Chinese Med, Dept Postgrad, Jinan 250014, Peoples R China; [Zhang, Juan; Yan, Yongjian; Chen, Wenwen] Shandong Acad Occupat Hlth & Occupat Dis, Jinan 250062, Peoples R China; [Chi, Mingfeng] Athletes Rehabil Ctr ShanDong Prov, Jinan 250014, Peoples R China; [Sun, Peng] Luye Pharmaceut Ltd Co, Dept Pharmaceut Anal, Yantai 264003, Peoples R China; [Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Lab Biol Resources, Yantai 264003, Shandong, Peoples R China |
| 通讯作者 | Qin, S (reprint author), Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 作者部门 | 生物资源实验室 |
| 英文摘要 | To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-induced acute lung injury, rats were divided into control, PQ-treated and PQ + PC-treated groups. Rats in PQ-treated group were orally administered with 50 mg/kg PQ and rats in PQ + PC-treated group were intraperitoneally injected with 50 mg/kg PC after administration of PQ. At 8, 24, 48 and 72 h after treatments, GSH-Px and SOD activities, MDA levels in plasma and BALF, HYP, NF-kappa B, I kappa B-alpha and TNF-alpha contents in lung tissues were measured. The pathological changes in lung were observed. After treatment with PC, the levels of MDA and the relative contents of NF-kappa B and TNF-alpha were significantly decreased, the activities of GSH-Px and SOD and the relative contents of I kappa B-alpha were significantly increased. The degree of rat lung damage was obviously reduced in PQ + PC-treated group. The results suggested that PC treatment significantly attenuated PQ-induced acute lung injury. (C) 2011 Elsevier B.V. All rights reserved.; To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-induced acute lung injury, rats were divided into control, PQ-treated and PQ + PC-treated groups. Rats in PQ-treated group were orally administered with 50 mg/kg PQ and rats in PQ + PC-treated group were intraperitoneally injected with 50 mg/kg PC after administration of PQ. At 8, 24, 48 and 72 h after treatments, GSH-Px and SOD activities, MDA levels in plasma and BALF, HYP, NF-kappa B, I kappa B-alpha and TNF-alpha contents in lung tissues were measured. The pathological changes in lung were observed. After treatment with PC, the levels of MDA and the relative contents of NF-kappa B and TNF-alpha were significantly decreased, the activities of GSH-Px and SOD and the relative contents of I kappa B-alpha were significantly increased. The degree of rat lung damage was obviously reduced in PQ + PC-treated group. The results suggested that PC treatment significantly attenuated PQ-induced acute lung injury. (C) 2011 Elsevier B.V. All rights reserved. |
| 文章类型 | Article |
| 资助机构 | Shandong Education Department[J07YD09] |
| 收录类别 | SCI |
| 语种 | 英语 |
| 关键词[WOS] | FACTOR-KAPPA-B ; LIPID-PEROXIDATION ; ENDOTHELIAL-CELLS ; TOXICITY ; INTOXICATION ; ANTIOXIDANTS ; MACROPHAGES ; POISONINGS ; KINETICS |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| WOS记录号 | WOS:000294936700008 |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.yic.ac.cn/handle/133337/5362 |
| 专题 | 海岸带生物学与生物资源利用重点实验室_海岸带生物学与生物资源保护实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Shandong Univ Tradit Chinese Med, Dept Postgrad, Jinan 250014, Peoples R China 3.Shandong Acad Occupat Hlth & Occupat Dis, Jinan 250062, Peoples R China 4.Athletes Rehabil Ctr ShanDong Prov, Jinan 250014, Peoples R China 5.Luye Pharmaceut Ltd Co, Dept Pharmaceut Anal, Yantai 264003, Peoples R China 6.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Lab Biol Resources, Yantai 264003, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Yingxin,Zhang, Juan,Yan, Yongjian,et al. The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2011,32(2):168-174. |
| APA | Sun, Yingxin.,Zhang, Juan.,Yan, Yongjian.,Chi, Mingfeng.,Chen, Wenwen.,...&Qin, Song.(2011).The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,32(2),168-174. |
| MLA | Sun, Yingxin,et al."The protective effect of C-phycocyanin on paraquat-induced acute lung injury in rats".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 32.2(2011):168-174. |
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